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- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Patients with chronic diseases that could … Patients with chronic diseases that could induce fatigue, such as chronic renal failure, fibromyalgia, chronic anemia, and untreated hypothyroidism or with problems in the oral mucosa unrelated to the cancer. </br>Patients with untreated depression and anxiety.nts with untreated depression and anxiety.)