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- Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study + (Patients with maligancies of GIT, nausea and vomiting due to reasons other than chemotherapy, hypertension and renal or liver insufficiency)
- Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (Patients with metastatic disease, diarrhea before radiotherapy, radiochemotherapy, or supplementation of selenium before radiotherapy, as well as patients who had undergone previous pelvic radiotherapy)
- Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer + (Patients with multiple-day chemotherapy; r … Patients with multiple-day chemotherapy; receiving concurrent radiotherapy with high risk of causing emesis (i.e., total body, hemi body, upper abdomen, and craniospinal radiation); taking therapeutic doses of warfarin, aspirin, or heparin; had a history of bleeding disorder(s) like severe thrombocytopenia; had an allergy to ginger or chamomile or had taken it in the last week; had gastrointestinal disorders and cancers; and had other emesis-inducing diseases, such as hypertension, liver, and renal failure. </br></br>Further exclusion of patients who met the following criteria: forgotten to take capsules ≥3 consecutive times; used other antiemetic drugs or therapeutic methods except the routine antiemetic; had severe gastrointestinal problems during the study; and refusal to continue participating in trial.efusal to continue participating in trial.)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Patients with other malignancies, being allergic to ginger, perfumes or cosmetics or patients undergoing concurrent radiotherapy)
- Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy + (Patients with past history of irradiation; diarrhea before the beginning of pelvic irradiation, taking another drug for treatment of diarrhea during the study, unwilling to participate in the study at any time)
- Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer + (Patients with prior upper aerodigestive tract cancers within the past 5 years, or with synchronous cancers of the esophagus or lung)
- Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Patients with recurrent disease, synchronous multiple tumors, previous malignant disease, abnormal liver or renal function, hypertriglyceridemia, hypercholesterolemia, diabetes mellitus, hypertension, and recent or active peptic ulcer)
- Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (Patients with significant cardiac, renal or neurologic comorbidities, or an active state of malnutrition, diabetes, pregnancy, and Karnofsky index less than 70)
- Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (Patients with symptomatic brain metastases … Patients with symptomatic brain metastases; </br>- scheduled to receive or having received, in the past 4 weeks, radiotherapy to upper abdomen or craniospinal region; </br>- emesis or significant nausea within 24h before the first HEC cycle; </br>- coagulation disorders or current therapy with oral anticoagulants; </br>- planned surgery during the study period or within 2 weeks after its conclusion; </br>- prior seizures; </br>- cannabinoids or current/past drug or alcohol abuse; </br>- use of other investigational drug(s) within 30 days before study entry or during the study; </br>- any relevant condition potentially interfering with study evaluation; </br>- known hypersensitivity to ginger or any components of the product.o ginger or any components of the product.)
- Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (Patients with xerostomia, previous salivar … Patients with xerostomia, previous salivary gland dysfunction, salivary stone or tumor, those who had undergone head and neck radiotherapy previously, who had known rheumatological diseases such as Sjögren’s disease, who had been administered <sup>131</sup>I earlier, who had known liver disease, had taken drugs influencing salivary gland function, such as antihistaminic agents, beta-blockers, atropine, benzodiazepines, tricyclic antidepressants, and antipsychotic drugs in the past 2 weekspressants, and antipsychotic drugs in the past 2 weeks)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (People who had other types of cancer, whos … People who had other types of cancer, whose cancer recurred before the treatment, who had mental and psychiatric diseases, and who had contraindications for foot massage (such as disseminated edema, a pacemaker, a history of myocardial infarction, uncontrolled hypertension, active gout, deep vein thrombosis history, gallbladder or kidney stones, acute infection, fever, or a fracture or wound on the feet)fever, or a fracture or wound on the feet))
- Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (People with metastases outside the abdominal area; bad general condition (Karnofsky index < 50%); previous immunosuppressive treatment; current pregnancy; older than 75 years or younger than 18 years; known WOBE-MUGOS intolerance)
- Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Peyronie’s disease, hormonal abnormalities … Peyronie’s disease, hormonal abnormalities, any drug consumption that could interact with sildenafil or carnitines as indicated on the technical form, recent (less than 6 months) myocardial or cerebral ischemia or major surgery, alcohol or tobacco abuse, alterations in aspartate and alanine transaminase levels, compensated or uncompensated diabetes, and uncompensated hypertension or hypotension uncompensated hypertension or hypotension)
- Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Pregnancy or lactation, nausea or vomiting … Pregnancy or lactation, nausea or vomiting prior to chemotherapy administration, presence of conditions that may cause nausea or vomiting (e.g., brain metastasis, bowel obstruction, hepatitis, or recent abdominal or pelvic irradiation within 1 week), bleeding diathesis, allergy to ginger, or concomitant treatment with other chemotherapy.omitant treatment with other chemotherapy.)
- Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Pregnant or lactating, or planning to beco … Pregnant or lactating, or planning to become pregnant; history of hypersensitivity or severe adverse reaction to fluoropyrimidines; serious concurrent disease (including interstitial pneumonia, pulmonary fibrosis, intestinal paralysis, ileus, poorly controlled diabetes, liver cirrhosis or hepatitis (type B or C), poorly controlled hypertension, history of myocardial infarction or unstable angina within past 6 months); active multiple primary cancer (disease-free less than 5 years); concurrent infectious disease; judged to be unsuitable for participation in the clinical study by the investigator for any other reasony by the investigator for any other reason)
- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Presence of distant metastases; a previous history of salivary gland disorders, collagen tissue disease, diabetes, previous 131I therapy, or external radiation to the head or neck; or difficulty drinking a large amount of water.)
- Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy + (Previous chemotherapeutic treatment or regimens including other neurotoxic drugs associated with cisplatin)
- Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy + (Previous chemotherapeutic treatment or regimens including other neurotoxic drugs associated with cisplatin)
- Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Previous chemotherapy; brain metastasis; double tumour; lack of tolerance to polychemotherapy due to performance status, age or comorbidities)
- Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (Previous history of autoimmune or chronic … Previous history of autoimmune or chronic inflammatory disease, radiotherapy and cytotoxic chemotherapy had previously been administered, use of medicine with the aim of mucositis prophylaxis, less than one-third of buccal mucosa was in the radiotherapy region, patient refused entryradiotherapy region, patient refused entry)
- Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial + (Previous history of peripheral neuropathy … Previous history of peripheral neuropathy or symptomatic peripheral neuropathy at entry into the study, received other chemotherapy regimens, currently receiving anticoagulants, platelet aggregation inhibitors, opioids, anticonvulsants, tricyclic antidepressants, and previous history of hemorrhagic strokeand previous history of hemorrhagic stroke)
- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (Previous history of radiation therapy, chemotherapy or surgery; WHO performance index below 70%; uncontrolled systematic diseases)
- Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (Previous or simultaneous radiotherapy in the head and neck region, including the nasopharynx, oropharynx, and larynx; previous head and neck surgery due to malignancy; use of dentures; pregnancy; infection)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Previous radiotherapy for head and neck cancer, double cancers, diabetes mellitus)
- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Previous radiotherapy in the head or neck area; functional disorders of the bone marrow, liver or kidneys; allergy to aloe)
- Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Previous radiotherapy of the head and neck; diabetes)
- Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Previous radiotherapy of the head and neck; diabetes mellitus)
- Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Previous radiotherapy of the head and neck; diabetes mellitus)
- Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Previous radiotherapy; allergies to aloe; diabetes mellitus; HIV)
- Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Previous treatment for HFS; hypersensitivity to pyridoxine; immunosuppression or positive human immunodefciency virus (HIV) serology)
- Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Previously diagnosed with cancer, had other concomitant cancers, distant metastases or recurrent cancer, had undergone prior radiation therapy or chemotherapy, or had received drug containing zinc)
- Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Prior cytotoxic chemotherapy (except estra … Prior cytotoxic chemotherapy (except estramustine monotherapy), bone-seeking radioisotope therapy, prior untreated CNS involvement, or malignancy other than prostate cancer (except adequately treated basal or squamous cell skin cancer or any other cancer from which the individual had been disease free for > 5 years), history of hypercalcemia or vitamin D toxicity, active uncontrolled infection, symptomatic peripheral neuropathy of grade > 2, or hypersensitivity to any treatment component;</br>use of calcium supplements higher than 500 mg and pharmacologic doses of vitamin D or its derivatives (> 400 U or 10 μg) vitamin D or its derivatives (> 400 U or 10 μg))
- Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (Prior exposure to neurotoxic, not have had … Prior exposure to neurotoxic, not have had any of the following conditions: coronary artery disease, congestive heart failure, diabetes (requiring pharmacologic intervention), head or neck cancers, or a history of a hemorrhagic stroke, pregnant or nursing women, concomitant use of anticoagulants, platelet aggregation inhibitors, opioids, anticonvulsants, tricyclic antidepressants, other neuropathic pain medication agents, or vitamin E, not have been receiving radiationtamin E, not have been receiving radiation)
- Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Prior radiation therapy; patients with distant metastasis, Kornovsky Index <70; altered hematological or biochemical parameters)
- Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Radical mastectomy)
- Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (Radiotherapy)
- Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Radiotherapy in the past year; food allergy; hypersensitivity to benzydamine, NSAIDs, or aloe; existing lesions in the oral cavity)
- Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Radiotherapy of the brain or for gynaecological cancers)
- Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (Received previous aromatase inhibitor trea … Received previous aromatase inhibitor treatment, had a history of rheumatoid arthritis, hypercalcemia or were taking excluded medications, unwilling to discontinue other oral supplements containing D3 and/or calcium;</br>patients with osteoporosis in some cases; patients with osteoporosis in some cases)
- Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (Receiving hospice care at intake, residing … Receiving hospice care at intake, residing in a nursing home or similar care facility, being bedridden, regularly using CAM similar to those used in the protocol (e.g., reflexology, foot massage, pedicure with massage), and participating in an experimental chemotherapy protocol. in an experimental chemotherapy protocol.)
- Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Receiving prior treatment for advanced or metastatic disease; taking 2000 IU/d or greater of vitamin D<sub>3</sub>, had symptomatic genitourinary stones within the past year, or were taking thiazide diuretics.)
- Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (Receiving prior treatment for advanced or metastatic disease; taking 2000 IU/d or greater of vitamin D3, had symptomatic genitourinary stones within the past year, or were taking thiazide diuretics.)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Scleroderma, large breast with an inter-field of more than 25cm, or prior radiotherapy to the same breast, indication to lymph node irradiation)
- Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Second malignancy within 5 years (excludin … Second malignancy within 5 years (excluding basal or squamous cell carcinoma of the skin treated curatively); brain metastasis; nephrolithiasis within 10 years; chronic hypercalcemia (i.e., serum calcium >1.0 mg/dL the upper limit of normal); chronic gastrointestinal disease (i.e., malabsorption, surgery affecting absorption, and chronic ulcerative colitis); urinary protein >4 g/24 h; urinary calcium ≥500 mg/24 h; active angina, New York Heart Association class II–IV heart failure, or history of myocardial infarction within 6 month; uncontrolled infection; or hypersensitivity to polysorbate 80, use of digitalis, thiazide diuretics, calcium supplements, anticonvulsants, fluoride, and lithium was not allowed, use of steroids was permitted unless taken for prostate cancer;</br>treatment with suramin, strontium, or other therapeutic radioisotopesor radiotherapy within 4 weeksutic radioisotopesor radiotherapy within 4 weeks)
- Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (Self-reported allergy to aloe vera; breast infection; indication for nodal irradiation)
- Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (Suffering from any other underlying diseas … Suffering from any other underlying diseases; being addicted to cigars, tobacco and opioid</br>drugs; having a history of sensitivity to aloe vera; developing any kind of sensitivity to any material during the study; developing any acute condition during the study; and unwillingness to continue participation in the studyess to continue participation in the study)
- Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (Symptomatic metastatic disease; anticipati … Symptomatic metastatic disease; anticipation of needing secondary prostate cancer therapy within the next 6 months; current use of weight loss medications or enrollment in a diet/weight loss program; current therapy aimed at lowering testosterone levels (including GnRH agonist/antagonist; prior bilateral orchiectomy; oral anti-androgens, or 5-alpha reductase inhibitors; testosterone replacement was allowed but treatment should be stable during the entire study); already consuming an low carbohydrate diet; being vegetarian/vegan; weight loss >5% of body weight in the last 6 months based on self-report; medical comorbidities that in the opinion of the investigator limits the patient’s ability to complete the studys the patient’s ability to complete the study)
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (The exclusion criteria included allergy to ginger, history of chemotherapy, history of other malignancy in women, reception of vitamin E and omega-3 before or concurrent with chemotherapy, chemotherapy intolerance and patients with stage 4 ovarian cancer.)
- Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (Those already receiving (or who had receiv … Those already receiving (or who had received in the past two months or who were intending to receive during the period of the study) either aromatherapy massage or reflexology from any practitioner and those unable to receive the intervention due to contraindications or precautions for either therapy.cations or precautions for either therapy.)
- Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Tumors that were not resectable by surgery, serious post-operative complications before starting supplementation, pathological diagnosis other than epithelial carcinoma (such as malignant lymphoma and sarcoma), and pathological stage 0 or IV)
- Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Uncontrolled diabetes; uncontrolled eating … Uncontrolled diabetes; uncontrolled eating disorders; acquired immunodeficiency syndrome, active lupus or scleroderma; known allergy to pure aloe; inability to complete the screening and informed consent procedures before receiving a total of 10 Gy of radiationre receiving a total of 10 Gy of radiation)