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- Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Uncontrolled diabetes; uncontrolled eating … Uncontrolled diabetes; uncontrolled eating disorders; acquired immunodeficiency syndrome, active lupus or scleroderma; known allergy to pure aloe; inability to complete the screening and informed consent procedures before receiving a total of 10 Gy of radiationre receiving a total of 10 Gy of radiation)