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List of results

• Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial  + (Intervention arm: n=173 (69%) male, n=78 (31%) female placebo arm: n=103 (62%) male, n=63 (38%) female)
• Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial  + (Intervention arm: n=32 (64%) male, n=18 (36%) female; placebo arm: n=27 (49%) male, n=28 (51%) female)
• Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study  + (Intervention arm: n=40 (81.6%) male, n=9 (18.4%) female Placebo arm: n=43 (89.6%) male, n=5 (10.4%) female)
• Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study  + (Intervention arm: n=40 (81.6%) male, n=9 (18.4%) female Placebo arm: n=43 (89.6%) male, n=5 (10.4%) female)
• Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial  + (Intervention arm: n=41 (59%) male, n=28 (41%) female; placebo arm: n=38 (54%) male, n=32 (46%) female)
• Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA  + (Male n (%): 86 (100))
• Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer  + (Male n (%): 92 (100))
• Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study  + (Male n(%) per arm: Green tea arm: 2 (13), Metronidazole arm: 1 (7) Female n(%) per arm: Green tea arm: 13 (87), Metronidazole arm: 14 (93))
• Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy  + (Male n(%) per arm: Green tea arm: 9 (42.9), placebo arm: 14 (66.7) Female n(%) per arm: Green tea arm: 12 (57.1), placebo arm: 7 (33.3))
• Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer  + (Male n(%) per arm: Selenium arm: 25 (67.9), placebo arm: 25 (73.5) Female n(%) per arm: Selenium arm: 12 (32.1), placebo arm: 9 (26.5))
• Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial  + (Male n(%) per group: ginger-group: 53 (74.65), placebo-group: 47 (68.12) Female n(%) per group: ginger-group: 18 (25.35), placebo-group: 22 (31.88))
• Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients  + (Male n=31, female n=8)
• Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)  + (Male per arm: THC = 54% Cannabis extract = 56% Placebo = 52%)
• Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2)  + (Male, n (%): 57 (100))
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Male, n(%) per arm: Sativex = 106 (53.0) Placebo = 97 (48.7) Female, n(%) per arm: Sativex = 194 (47.0) Placebo = 102 (51.3))
• Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients  + (N (%) of men per arm: - intervention: 223 (82) - placebo: 203 (76))
• Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients  + (N (%) of men per arm: - intervention: 223 (82) - placebo: 203 (76))
• Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients  + (N (%) of men per arm: - intervention: 223 (82) - placebo: 203 (76))
• Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial  + (N (%) per arm: - intervention: 94 (90.4) male, 10 (9.6) female - control: 99 (90) male, 11 (10) female)
• Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization  + (NA)
• Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial  + (NA)
• Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology  + (NA)
• Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy  + (NA)
• Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy  + (NA)
• Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial  + (NA)

• Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients  + (NI)
• Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study  + (NI)
• Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life  + (NI)
• Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial  + (NI)
• Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study  + (NI)
• Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme  + (NI)
• Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy  + (NI)
• Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients  + (NI)

• Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study  + (Nasopharyngeal cancer: intervention arm: 17 (81.0%) male, 4 (19.0%) female Nasopharyngeal cancer: placebo arm: 15 (78.9%) male, 4 (21.1%) female Oral cancer: intervention arm: 19 (83.0%) male, 4 (17%) female Oral cancer: placebo arm: 20 (100%) male)
• Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer  + (Number male, female per group: - intervention: 36/50, 14/50 - placebo: 37/50, 19/50)
• Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial  + (Number n (Male/Female): Arm A: 2/16 Arm B: 3/15 Arm C: 7/12 Arm D: 2/15)
• Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy  + (Of the 17 analysed patients: 15 male, 2 female)
• Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer  + (Overall 11.1% female, male/female per arm: - intervention: 22/3 - placebo: 18/2)
• Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...)  + (Overall 36% female, male/female per arm: - intervention: 29/11 - control: 24/19)
• Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture  + (Overall 78% female; male/female per arm: - electroacupuncture arm: 4/10 - hydroelectric bath arm: 1/12 - vit. B arm: 5/10 - placebo arm: 3/14)
• Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Part A Female = 176 (43.6%) Part B Sativex = 40 (38.8%) female Placebo = 48 (46.6%) female)
• Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment  + (Patients: 100 % female; Caregivers: 40,8 % female)
• Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial  + (Per group - placebo: 29 male, 21 female - intervention: 28 male, 22 female)
• Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer  + (Per group n (%) - intervention: male 113 (84%), female 22 (16%) - placebo: male 101 (78%),female 28 (22%))
• Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics  + (SRT501 (resveratrol): Male (5), female (1) Placebo: Male (1), female (2))
• Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study  + (Sex (%) per arm * Megestrol Acetate: male = 65; female = 36 * Dronabinol: male = 66; female = 34 * Megestrol Acetate + Dronabinol: male = 66; female = 34)
• Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial  + (n=120 (49%) male and n=124 (51%) female)
• Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation  + (n=14 male (78%), n=4 female (22%))
• Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders  + (n=41 female)
• Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation  + (n=6 female (intervention arm=22.3%; control arm=44.4%))