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List of results

Kadhim et al. (2021): Effect of Ginger Tea on Chemotherapy-Induced Nausea and Vomiting among Patients Attending the Oncology Teaching Hospital, Baghdad 2020 + (?)
Montazeri et al. (2013): Iranian Red Crescent Medical JournalEﬀect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients. + (?)
Sharp et al. (2009): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (?)
Williams et al. (1996): Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity + (?)

Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (A confirmed diagnosis of prostate cancer ( … A confirmed diagnosis of prostate cancer (stage I-IV) with no bone metastases; being within six months of starting androgen deprivation therapy (ADT) with an additional six more months planned; suboptimal vitamin D levels (<32 ng/ml); total serum calcium ≤10.5 mg/dl; no contraindications for fitness testing and 5) ≥60 years oldions for fitness testing and 5) ≥60 years old)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (A histopathological diagnosis of epithelia … A histopathological diagnosis of epithelial carcinoma of the digestive tract (esophagus, stomach, small intestine, colon, and rectum), clinical stages I to III; aged 30 to 90 years at entry; diagnosis and initial surgery at the International University of Health and Welfare Hospital; not taking vitamin D supplements or active vitamin D; and no history of urinary tract stones D; and no history of urinary tract stones)
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Above 18 year-old and newly diagnosis with … Above 18 year-old and newly diagnosis with histology of solid tumors with Eastern Cooperative Oncology Group (ECOG) performance status B2. All patients must complete surgical resection of primary tumor and planned for at least 3 consecutive cycles of moderately to highly emetogenic adjuvant chemotherapy for curative intent adjuvant chemotherapy for curative intent)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (Adult (>18years) patients of either gender with solid tumors and chemotherapy-naive who were planned to receive more than 2 cycles of HEC with cisplatin (single dose >50 mg/m2 every 21 or 28 days))
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Adult male or female patients, who had bee … Adult male or female patients, who had been using strong opioids for at least one week to relieve pain associated with incurable malignancy; pain severity score of 4 or above on a 0-10 Numerical Rating Scale (NRS) on both days of the two-day baseline periodn both days of the two-day baseline period)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Adult patients (≥18 years of age) with his … Adult patients (≥18 years of age) with histologic evidence of an incurable malignancy other than brain, breast, ovarian, or endometrial cancer; estimated life expectancy of ≥3 months; Eastern Cooperative Oncology Group performance status of 0 to 2, as judged by their primary oncologist; self-reported weight loss of at least 5 pounds (2.3 kg) during the preceding 2 months and/or a physician-estimated caloric intake of less than 20 calories/kg of body weight per day; believe, that loss of appetite or loss of weight was an ongoing probleme or loss of weight was an ongoing problem)
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Adult patients with a confirmed diagnosis … Adult patients with a confirmed diagnosis of solid or nonmyeloid malignancy scheduled to receive six courses of cumulative DDP-based regimens were enrolled if they had satisfactory liver and renal function, a life expectancy of at least 9 months, and a WHO performance score of 0–1.onths, and a WHO performance score of 0–1.)
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (Adult patients with a confirmed diagnosis … Adult patients with a confirmed diagnosis of solid or nonmyeloid malignancy scheduled to receive six courses of paclitaxel-based chemotherapy regimen were enrolled if they had satisfactory liver and renal function, a life expectancy of at least 9 months, and a WHO performance score of 0–1.onths, and a WHO performance score of 0–1.)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Adult patients with active cancer and chronic pain (moderate or severe despite a stable opioid regimen that could not be made more effective by further opioid dose titration); stable, average pain: NRS: ≥4≤ 8 (no change in 3 days > 2 points))
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Adult woman (22-70 years) with Mamma-carcinoma)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (Adults with a histological diagnosis of cancer at any stage who were receiving systemic chemotherapy.)
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (Advanced cancer; ≥18 years of age; clinica … Advanced cancer; ≥18 years of age; clinical diagnosis of cancer-related pain that was unalleviated by an optimized maintenance dose of Step 3 opioid therapy (opioid therapy considered optimized if: 1) a dose increase was clinically inappropriate due to opioid-related side effects or 2) further efficacy benefit was not expected at higher doses (for the second definition, patients had to be receiving ≥90 mg morphine equivalents/day, inclusive of maintenance, and breakthrough opioids); each of three consecutive days during the screening period: ≥four opioid breakthrough analgesic episodes per day (averaged over the three days); a stable maintenance opioid therapy dose; average pain ≥four and ≤eight on a 0-10 Numerical Rating Scale (NRS); average pain scores on the NRS that did not change by more than two points (i.e., no more than a two-point difference between the highest and lowest scores, with all scores remaining between four and eight)l scores remaining between four and eight))
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Advanced incurable stage of cancer; ≥ 18 y … Advanced incurable stage of cancer; ≥ 18 years of age; clinical diagnosis of cancer-related pain unalleviated by an optimized maintenance dose of Step 3 opioid therapy; ≤ 4 opioid breakthrough analgesic episodes per day (averaged over the 3 days); stable maintenance opioid therapy dose; average pain ≥ 4 and ≤ 8 on a 0–10 NRS; average pain scores on the NRS that did not change by more than 2 points from the beginning to end of screening (i.e. no more than a 2-point difference between the highest and lowest scores, with all scores remaining between 4 and 8 with all scores remaining between 4 and 8)
Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Advanced incurable stage of cancer; ≥18yea … Advanced incurable stage of cancer; ≥18years of age; clinical diagnosis of cancer-related pain unalleviated by an optimized maintenance dose of Step 3 opioid therapy; ≤4 opioid breakthrough analgesic episodes per day (averaged over the 3 days); stable maintenance opioid therapy dose; average pain ≥ 4 and ≤8 on a 0–10 NRS; average pain scores on the NRS that did not change by more than 2 points from the beginning to end of screening (i.e. no more than a 2-point difference between the highest and lowest scores, with all scores remaining between 4 and 8 with all scores remaining between 4 and 8)
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (Advanced, incurable cancer; cancer-related … Advanced, incurable cancer; cancer-related anorexia-cachexia syndrome; weight loss (≥ 5% over 6 months), not explained by other diseases or recent surgery; Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤ 2: estimated life expectancy of 3 months; Creatinine, bilirubin, and transaminase values no higher than 3x the maximum normal value; Unchanged antineoplastic therapy for 4 weeks and unchanged supportive treatment (analgesics, sedatives, tranquilizers, and anticholinergics) for 1 week before baseline assessmentscs) for 1 week before baseline assessments)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (Age > 18 years; acute myeloid leukaemia (AML) or acute lymphoblastic leukaemia (ALL); being under chemotherapy)
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Age > 18 years; squamous cell carcinoma … Age > 18 years; squamous cell carcinoma of the mouth, pharynx or larynx; performance status 0-1; ability to eat an adequate oral diet; no previous radiotherapy in the head and neck region; adequate bone marrow, liver and renal functions; no history of allergies to testing compounds no history of allergies to testing compounds)
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Age of at least 18 years; a diagnosis of lung cancer; patients receiving cisplatin-based regimens; patients receiving standard antiemetic therapy (5-HT3 RAs); the ability to swallow capsules; nonuse of self-prescribed therapies or complementary products)
Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (Age over 18 years, a dose of radiation rec … Age over 18 years, a dose of radiation received over 4,500 cGy, the radiation received during the period 6 to 7 weeks, minor and major salivary glands involvement, one or two sides of the face in the field of radiation, and over the last three months of receiving radiation. last three months of receiving radiation.)
Montazeri et al. (2013): Eﬀect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients + (Age over 18, having the experience of chem … Age over 18, having the experience of chemotherapy with nausea and vomiting, having at least two chemotherapy episodes. Consists of 50-100 mg Cisplatin, with or without other chemotherapy agents with similar amount and prescription in two chemotherapy cycles without having any plans for radiotherapy among cycles, presence in ward for 24 hours ( in order to investigate the PRN), having no nausea and vomiting experiences for some reasons except for chemotherapy, lack of receiving PRN in 24 past hours, lack of treatment with corticosteroid drugs during considered cycles, lack of aﬄictions to hepatitis, digestion system block-age, brain malignancy and cerebral metastasis and clotting disorder on the basis of recorded information in ﬁles, lack of using the anti-clot drug in ﬁles, lack of using the anti-clot drug)
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (Age over 18, having the experience of chem … Age over 18, having the experience of chemotherapy with nausea and vomiting, having at least two chemotherapy episodes. Consists of 50-100 mg Cisplatin, with or without other chemotherapy agents with similar amount and prescription in two chemotherapy cycles without having any plans for radiotherapy among cycles; presence in ward for 24 hours ( in order to investigate the PRN; having no nausea and vomiting experiences for some reasons except for chemotherapy; lack of receiving PRN in 24 past hours; lack of treatment with corticosteroid drugs during considered cycles; lack of afflictions to hepatitis, digestion system blockage, brain malignancy and cerebral metastasis and clotting disorder on the basis of recorded information in files; lack of using the anti-clot drugin files; lack of using the anti-clot drug)
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (Age ≥18 years; cancer in the pelvic area, radiotherapy and acute proctitis (ARP))
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Aged 18–75 years, Grade ≥3 neuropathy, as … Aged 18–75 years, Grade ≥3 neuropathy, as determined by NCI-CTC criteria version 3.0, while receiving paclitaxel, cisplatin or vinblastine treatment, and/or grade ≥2 neuropathy persisting for at least one month after the discontinuation of either drug, and neurotoxicity for <6 months; at least one abnormality on electrophysiological examination; Karnofsky physical score (KPS) of ≥60; absolute neutrophil count of ≥1.5×10<sup>9</sup>/l, hemoglobin count of ≥80 g/l, platelet count of ≥75×10<sup>9</sup>/l, total bilirubin counts of 1.5-fold less than normal value, glutamic-pyruvic transaminase (GPT/ALT) and glutamic-oxalacetic transaminease (GOT/AST) no more than 2.5-fold greater than the normal value; normal blood urea nitrogen, serum creatinine and electrocardiogram (ECG) findings. During the study, the use of steroids, analgesic or neuroprotectant drugs was not permitted.se of steroids, analgesic or neuroprotectant drugs was not permitted.)
Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (Aged 75 years or younger with recent resected stage II cutaneous malignant melanoma; Hematopoietic, hepatic, and renal functionality within normal ranges)
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa)
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Aged >18 years, had a radiotherapy field covering more than one-third of the buccal mucosa)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Aged >18 years, pathologically established stages III and IV advanced nasopharyngeal carcinoma (NPC), concomitant chemotherapy and radiotherapy (CCRT))
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (Aged less than 55 years, who were referred … Aged less than 55 years, who were referred to our institute for 131I therapy to ablate the remnant thyroid tissue or to treat metastatic tumor, were enrolled in this study; all patients were in a hypothyroid state with serum thyroid stimulating hormone levels higher than 25 mIU/llating hormone levels higher than 25 mIU/l)