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- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Age > 18 years; squamous cell carcinoma … Age > 18 years; squamous cell carcinoma of the mouth, pharynx or larynx; performance status 0-1; ability to eat an adequate oral diet; no previous radiotherapy in the head and neck region; adequate bone marrow, liver and renal functions; no history of allergies to testing compounds no history of allergies to testing compounds)