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List of results

Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Histologically proven advanced lung cancer … Histologically proven advanced lung cancer, gastrointestinal tract tumor, breast cancer orbrain glioblastoma; measurable neoplastic lesions; progression on classical chemotherapy, radiotherapy or endocrine therapy or poor clinical conditions precluding chemotherapy; patients were eligible after at least 1 month from the last chemotherapy course; life expectancy <6 monthsotherapy course; life expectancy <6 months)
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (Histologically proven cancer of the head and neck (Karnofsky’s performance status ≥70) who were to receive curative radiotherapy or chemoradiotherapy)
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Histologically proven metastatic cancer; histological diagnosis of lung cancer or gastrointestinal tumour; measurable lesions)
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (Histologically proven, advanced and irresectable adenocarcinoma of the pancreas (UICC Stage IV), had a Karnofsky performance status of >60)
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (Histology proven evidence of carcinomas of … Histology proven evidence of carcinomas of lung, breast and ovary and would be treated with 1st line or 2nd line chemotherapeutic drugs, patients receiving paclitaxel either as first line or second line chemotherapeutic drug, either as a single agent or in combinations and with baseline clinical evaluation negative for any existing peripheral neuropathy; when paclitaxel is administered as second like drug, the exact details of previous chemotherapeutic agents would be necessary; those who have already received platinum, vincristine would be included provided no peripheral neuropathy is detected at the time of enrollmentded no peripheral neuropathy is detected at the time of enrollment)
Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Histopathologically diagnosed as having NS … Histopathologically diagnosed as having NSCLC (adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, or large cell lung carcinoma); with stage IA to IIIA; aged 20 to 75 years at entry; diagnosed and operated at any one of four Jikei University Hospitals at Shimbashi, Kashiwa, Chofu, and Katsushika; with tumor totally resected; discharged without major complications; and could visit the Jikei University Hospitals (Tokyo, Japan) and be followed-up for as long as possibleand be followed-up for as long as possible)
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Hormone receptor positive invasive nonmeta … Hormone receptor positive invasive nonmetastatic breast cancer (Stage I-IIIB), had completed at least 8 weeks of anastrozole as adjuvant therapy prior to study entry, and were experiencing new or worsening musculoskeletal pain unrelated to any history of trauma;serum 25OHD level between 10 and 29 ng/ml, serum calcium B10.3 mg/dl, and 24 h urine calcium excretion B250 mg/g creatinineine calcium excretion B250 mg/g creatinine)
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Karnofsky’s performance status ≥70, receiving curative radiotherapy or chemoradiotherapy, planned treatment was at least 6000cGy total radiation dose of external beam radiotherapy to at least one third of the oral cavity)
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Low-burden prostate cancer; choosing activ … Low-burden prostate cancer; choosing active surveillance for disease management; histologically documented prostate adenocarcinoma; extended pattern biopsy within 2 years of enrollment with a Gleason sum six or lower with no pattern four or five; no more than 33% of biopsy cores positive for cancer; no more than 50% of the length of a tumor core involved by carcinoma; three serum prostate-specific antige (PSA) levels done at least 2 weeks apart over the year prior to randomization; all PSA levels <10 ng/ml; life expectancy >3 months; ECOG (Eastern Cooperative Oncology Group) performance score <2Cooperative Oncology Group) performance score <2)
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Lung or breast cancer, 21 years or older; Patients who speak english and give informed consent)
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study + (Malignancy confirmed by histopathology, co … Malignancy confirmed by histopathology, combination chemotherapy including cyclophosphamide, occurrence of at least 2 episodes of vomiting in previous chemotherapy cycle and age above 18 years.All patients received cyclophosphamide 500-1000 mg I.V. in combination with other chemotherapeutic agents.nation with other chemotherapeutic agents.)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Men with histopathologically or cytologica … Men with histopathologically or cytologically proven metastatic adenocarcinoma of the prostate with evidence of progression (the development of new metastatic lesions or rising PSA) despite standard hormonal management (orchiectomy, gonadotropin-releasing hormone agonist or antagonist including withdrawal of antiandrogens, if applicable; 6 weeks for bicalutamide, 4 weeks for flutamide or nilutamide) were eligible;serum PSA ≥ 5.0 ng/mL, serum testosterone level ≤ 50 ng/dL, Eastern Cooperative Oncology Group performance status ≤ 2, life expectancy ≥ 3 months, age ≥ 18 years, patient agreement to use adequate contraception, and patient ability to give informed consent. patient ability to give informed consent.)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Men, 40 to 84 years old at baseline (1982), who received radiation therapy)
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (Minimum age of 18 years, presence of head … Minimum age of 18 years, presence of head and neck cancer, minimum radiation dose of 50 Gy (the least dose resulting in mucositis), the ability of patient to use topical gel (by his/her or examiner’s report), minimally 50% of patient’s oral cavity in radiation field (according to the radiotherapist’s opinion)according to the radiotherapist’s opinion))
Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study + (Moderate to severe fatigue, a Karnofsky Pe … Moderate to severe fatigue, a Karnofsky Performance Status (KPS) score 14 of 50 or more, and carnitine deficiency; carnitine deficiency was defined as free carnitine less than 35 µmol/L for males or less than 25 µmol/L for females (normal range 35-67 and 25-55, respectively), or an acyl-carnitine ratio of more than 0.4 (acylcarnitine ratio 0.4 total acyl-carnitine - free acyl-carnitine/free acyl-carnitine)- free acyl-carnitine/free acyl-carnitine))
Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (Must have had hot flashes for at least 1 m … Must have had hot flashes for at least 1 month with a frequency of at least 14 times per week. Women had to have a life expectancy of 6 months or more and a performance status of O or 1 on the Eastern Cooperative Oncology Group scale; use of the antiestrogen tamoxifen was allowed of the antiestrogen tamoxifen was allowed)
Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization + (NA)
Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial + (NA)
Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (NI)
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (NI)
Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (NI)
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (NI)
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (NI)
Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients + (Newly diagnosed non-Hodgkin’s lymphoma (NHL) of intermediate and high grade)
Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9 + (Newly diagnosed; chemotherapy; chemo-naive)

Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (Normal renal and hepatic function, life expectancy of more than one year)

Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy + (Older than 18 years, had a histologically docu- mented diagnosis of head and neck cancer, and had a Karnof- sky Performance Status Scale score of at least 70)
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Older than 18 years, had histologically documented diagnosis of head and neck cancer, had a Kanofsky performance status at least 70)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Pathologically confirmed, unresectable loc … Pathologically confirmed, unresectable locally advanced or metastatic adenocarcinoma of the colon or rectum with measurable disease per version 1.1 of the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines; patients were eligible if they received prior neoadjuvant or adjuvant chemotherapy or chemoradiation as long as the last dose of treatment was more than 12 months prior to cancer recurrence; Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, normal baseline organ function, and no evidence of hypercalcemia or conditions predisposing to hypercalcemia (ie, hyperparathyroidism).o hypercalcemia (ie, hyperparathyroidism).)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (Pathologically confirmed, unresectable loc … Pathologically confirmed, unresectable locally advanced or metastatic adenocarcinoma of the colon or rectum with measurable disease per version 1.1 of the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines; patients were eligible if they received prior neoadjuvant or adjuvant chemotherapy or chemoradiation as long as the last dose of treatment was more than 12 months prior to cancer recurrence; Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, normal baseline organ function, and no evidence of hypercalcemia or conditions predisposing to hypercalcemia (ie, hyperparathyroidism).o hypercalcemia (ie, hyperparathyroidism).)
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Pathologically or cytologically proven ade … Pathologically or cytologically proven adenocarcinoma of the prostate, metastatic disease (documented by computed tomograpghy, magnetic resonance imaging, or bone scan), disease progression after medical or surgical castration (documented by PSA, radiologic imaging of soft-tissue lesions, and/or bone scan; life expectancy longer than 3 months, normal liver and kidney function, Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2, and testosterone lower than 50 ng/dL ≤ 2, and testosterone lower than 50 ng/dL)
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Patient inclusion criteria were: 1) age &g … Patient inclusion criteria were: 1) age >21, 2) stage III or IV breast cancer, 3) able to perform basic activities of daily living, 4) undergoing chemotherapy, targeted or hormonal therapy at the time of enrollment, 5) able to speak and understand English, 6) having access to a telephone, 7) able to hear normal conversation, and 8) cognitively oriented to time, place, and person (determined via recruiter). Friend/family caregiver inclusion criteria were 1) age >18, 2) able and willing to provide at least one 30-minute protocol session per week for four consecutive weeks, 3) able to speak and understand English, 4) access to a telephone, 5) able to hearnormal conversation, and 6) cognitively oriented to time, place, and person (determined via recruiter).e, place, and person (determined via recruiter).)
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (Patients affected by Multiple Myeloma (MM) eligible to auto-hematopoietic stem cell transplantation (HSCT))
Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer + (Patients between 20 and 60 years; histolog … Patients between 20 and 60 years; histological diagnosis of breast cancer, history of receiving at least one chemotherapy injection, receiving single-day cycles of chemotherapy (each cycle separated from next by≥2 weeks); experiencing vomiting in previous sessions, and having normal values of hematologic and biomedical laboratory parameters.ogic and biomedical laboratory parameters.)
Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial + (Patients diagnosed with a single, low‑grade, superficial bladder tumor, less than 3 cm in diameter, who had undergone TUR)
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (Patients diagnosed with non-metastatic pro … Patients diagnosed with non-metastatic prostate cancer (N0 and M0 as confirmed by negative chest X-ray, bone scintigraphy and pelvic MRI or CT); scheduled for either radical prostatectomy or high-dose radiotherapy consisting of a combination of high-dose rate brachytherapy and pelvic external beam radiotherapyrapy and pelvic external beam radiotherapy)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (Patients in remission after chemotherapy with taxanes, platinumderivatives, or vinca alkaloids and who presented with symptoms of CIPN)
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (Patients over 18 years old, with a diagnosis of cancer, attending the hospital as NHS out- patients, wishing to access complementary therapy treatment and able to attend the hospital for four, one-hour sessions.)
Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy + (Patients receiving standardized abdomen and pelvic irradiation 5000 cGy (1000 cGy weekly) for prostate, uterus, cervix, bladder, rectum and colon)
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (Patients referred to local curative radiot … Patients referred to local curative radiotherapy with external beam radiotherapy (EBRT), in combination with hormone ablation; Adenocarcinoma of the prostate must be histologically confirmed on biopsy; life expectancy greater than 5 years; no metastatic disease detected during physical examination, standard radiography, bone scan, and magnetic resonance spectroscopy (MRS); no prior hormone therapy, radiotherapy or systemic treatment for prostate cancer and no other malignancyor prostate cancer and no other malignancy)
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (Patients referred to local curative radiot … Patients referred to local curative radiotherapy with external beam radiotherapy (EBRT), in combination with hormone ablation; Adenocarcinoma of the prostate must be histologically confirmed on biopsy; life expectancy greater than 5 years; no metastatic disease detected during physical examination, standard radiography, bone scan, and magnetic resonance spectroscopy (MRS); no prior hormone therapy, radiotherapy or systemic treatment for prostate cancer and no other malignancyor prostate cancer and no other malignancy)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Patients scheduled to receive single-agent capecitabine chemotherapy for breast, colorectal, and other cancers)
Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients + (Patients suffering from gynaecological or head and neck cancer who were irradiated because of their disease)
Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (Patients who had all gross cancer removed … Patients who had all gross cancer removed (microscopic residual disease or residual margin involvement was allowed), scheduled to undergo curative-intent chemotherapy with either taxanes or platinum compounds, have a good performance status (ECOG 0-2), life expectancy ≥6 months, and not have preexisting peripheralneuropathy from any causesting peripheral neuropathy from any cause)
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (Patients who were chemotherapy-naïve, were … Patients who were chemotherapy-naïve, were due to receive a moderately- or highly-emetogenic chemotherapy regimen, were at least 18 years old, had a baseline Karnofsky score >60, had no known concurrent neoplasms or illnesses that induced nausea independent of chemotherapy, and did not self-prescribe therapies or complementary products used for nausea.es or complementary products used for nausea.)
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Patients who were older than 18 years; were examined with second and third stage colorectal cancer; received CRT during postoperative and preoperative periods; were able to speak, read, and understand Turkish; and had agreed to participate in the study.)
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (Patients who were pathologically diagnosed with breast cancer, receiving AC, CAF or TAC chemotherapy regimen, receiving at least 3 chemotherapy cycles)
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (Patients who were scheduled to have a sing … Patients who were scheduled to have a single-day chemotherapy regime and to receive a 5-HT3 receptor antagonist antiemetic and/or the antiemetic aprepitant.Patients with histologically confirmed diagnosis of cancer currently being treated with chemotherapy.Patients must also have received at least one previous chemotherapy treatment with the same chemotherapeutic agent and have experienced nausea or vomiting of any severity as a result of that treatment.ny severity as a result of that treatment.)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Patients with Acute Myeloid Leukemia or Ac … Patients with Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia, undergoing allogenic Hematopoietic Stem Cell Transplantation, all patients had adequate cardiac, pulmonary, renal, and hepatic function as determined by the institutional protocol+ baseline indicates a mild selenium deficiencyeline indicates a mild selenium deficiency)
Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial + (Patients with a confirmed histologic diagn … Patients with a confirmed histologic diagnosis of cancer of the oral cavity and oropharynx referred to Radiotherapy; Admission requirements consisted of: (1) a minimal irradiated buccal mucosal area 12.2 cm2 or greater; the limits of this area, measured on verification films, were the hard palate (superior), the floor of the mouth (inferior), the anterior border of the vertical portion of the mandible (posterior), and the distal border of the irradiation field (anterior); (2) age at least 21 years; (3) Zubrod performance status grade 2 or lower; (4) tolerance of solid food at study entry(4) tolerance of solid food at study entry)
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (Patients with a histological diagnosis of early stage breast cancer in an early stage (I or II) for whom adjuvant radiation therapy was indicated)