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Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + ( * More and cannabinoid typical side effec … * More and cannabinoid typical side effects in intervention arms, knowledge of assignment could have influenced the result. * No information whether centers were comparable in treatment of patients; especially “optimized” opioid treatment may vary from country to country treatment may vary from country to country )
Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + ( * More and cannabinoid typical side effec … * More and cannabinoid typical side effects in intervention arms, knowledge of assignment could have influenced the result.* No information whether centers were comparable in treatment of patients; especially “optimized” opioid treatment may vary from country to country treatment may vary from country to country )
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain +