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- Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Vitamin D3 supplementation and other nutri … Vitamin D3 supplementation and other nutritional supplements were not further monitored at the time of first cancer progression and data on subsequent therapies were not routinely collected, therefore type of treatment taken after patients withdrew from study that may have affected overall survival outcomes is not knownted overall survival outcomes is not known)