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- Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + ('''Area under curve''' Secondary criteria … '''Area under curve'''</br>Secondary criteria for efficacy were the areas under the curves in graphs for muscositis, skin reactions and dysphagia after commencement of radiation therapy. "Area under the curve" indicates the average score for muscositis, skin reactions and dysphagia; only patients with complete data set: Enzyme-arm: N=50, control-arm: N=43a set: Enzyme-arm: N=50, control-arm: N=43)