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- Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + ('''Changes''' The changes in skin dryness, … '''Changes'''</br>The changes in skin dryness, itchiness, burning sensation, and pain relative to the previous follow-up point were also scored using a 6-point Likert tool. The response options possible relative to the changes in symptoms were:</br></br>0=none; 1=unchanged; 2=slightly improved; 3=much improved; 4=slightly worse; 5=much worse. improved; 4=slightly worse; 5=much worse.)