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- Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (2 instances of grade 3 toxicity in the intervention arm, which was not reported with placebo)
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (5-year OS)
- Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (5-year overall survival = elapsed time from the date of randomization (ie, time from starting the study medication to the date of death due to any cause), as well as incidence of relapse, cancer- specific death, and noncancer death)
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (5-year overall survival: the time from the supplement start date to the date of death from any cause)
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (5-year recurrence-free survival: the time from the supplement start date to the earlier date of relapse of cancer or death from any cause)
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (?)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (?)
- Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Ability to oral intake; Amount of daily meals)
- Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients + (Acute Adverse Effects of Radiation Therapy … Acute Adverse Effects of Radiation Therapy:</br>most severe radiation therapy adverse effect with regards to baseline status, graded from 0 (no symptom) to 4 (severe symptom), in six sites (skin, mucosa, ear, salivary glands, pharynx and esophagus, and larynx)glands, pharynx and esophagus, and larynx))
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Adverse effects)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Adverse effects with CTCAE: pain, fatigue, nausea, vomiting, diarrhea, constipation, flatulence, urinary urgency and proctitis (week 1-5 of chemotherapy))
- Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (Adverse events)
- Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (All adverse events are reported regardless of perceived relationship to treatment)
- Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (All endpoints are mean values formed from four surveys that took place over each intervention day Observation of state of mind AARS: Positive affect)
- Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (Amount/weight of saliva, unstimulated)
- Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Anti-infective medicines in addition to usual care)
- Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (Antibiotic use, measured as the number of days with antibiotics in the previous 30 days)
- Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (Anxiety and Depression)
- Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (Anxiety and Depression (Baseline, 18 weeks post surgery, 24 weeks post surgery))
- Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Appetite)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Appetite with questionnaire (no further information))
- Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (Aromatase inhibitor-associated musculoskeletal symptoms)
- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (Aromatase inhibitor-induced arthralgia)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (At 3 months)
- Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (At baseline and T6 (Day 4 after chemotherapy))
- Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (At rest and while coughing Pain at 2h, 6h and 24h)
- Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Audiograms 2000/4000/8000 Hz and evoked brainstem responses)
- Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (Average tolerability scored by patient and doctor on a scale from 1=very good to 5=bad; Therpy result scored by patient and doctor on a scale from 1 to 4=unsatisfactory)
- Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (BMI and body composition (BIA) : baseline + 6, 12 weeks)
- Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (BMI, body weight, fat (%))
- Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial + (Baseline + every 2 months (for 3 years), then every 4 months (up to the 5th year), then twice a year)
- Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (Baseline within 24h after the 1st chemothe … Baseline within 24h after the 1st chemotherapy cycle and three further posttreamtent measurements, each 24h after the 2nd-4th chemotherapy cycle. Baseline within 24h after the 1st chemotherapy cycle and three further posttreamtent measurements, each 24h after the 2nd-4th chemotherapy cycle. </br>INVR: Subscale of experienceerapy cycle. INVR: Subscale of experience)
- Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (Baseline, Follow-up)
- Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (Baseline, Follow-up)
- Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (Baseline; T1-T3 (Day 2 post surgery - Day 4 post surgery, follow-up) Value; coefficient of the time x group interaction effect βI (standard error),p-value)
- Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (Before and after the 4 sessions: Change in values before and after treatment at the respective 4 points in time)
- Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...) + (Before the start of chemotherapy, every 6 weeks during chemotherapy, then every 3 months for up to 1 year Measures: EORTC QLQ-C30 (V.3) and Lung module QLQ-LC13)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Between the time of first treatment and th … Between the time of first treatment and the time of local recurrence or distant metastases;</br></br>Subgroup analysis: no significant difference between the arms for the 5-year DFS among the patients with stages III to IV head and neck cancers other than nasopharyngeal carcinoma (p = .752)r than nasopharyngeal carcinoma (p = .752))
- Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (Blinding)
- Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors + (Body composition measurements (mean percentage body fat and lean mass) were assessed using dual energy X-ray absorptiometry (DXA) in accordance with standardised procedures under the direction of a certified radiation technician.)
- Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Body weight)
- Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (Body weight, body mass index, muscle area, muscle attenuation, visceral adipose tissue area and subcutaneous adipose tissue area)
- Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors + (Body weight, height and waist and hip circumference were measured following standardised protocols (Khosla & Lowe, 1967; Lean et al., 1995))
- Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Bone Mineral Density of the lumbar spine, total femur, and femoral neck)
- Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Breakthrough pain and corresponding opioid intake and daily opioid use with diary Numeric Rating Scale (NRS) over the last 24h)
- Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (Breast cancer-specific QOL with FACT-B: physical, emotional, social, functional, breast cancer-specific concerns subscales and total scale)
- Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (Burning Sensation in the mouth)
- Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Burning sensation of the mouth and dysphag … Burning sensation of the mouth and dysphagia of solid food or liquids were recorded based on the patient reports and erythema and ulcers were observed clinically during weekly visits.</br></br></br>WHO Scale: </br></br>0 = None</br></br>1 = Soreness ± erythema</br></br>2 = Erythema, ulcers, patient can swallow solid food</br></br>3 = Ulcers with extensive erythema, patient can not swallow solid food</br></br>4 = Mucositis to the extent that alimentation is not possiblee extent that alimentation is not possible)
- Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (CINV symptoms: Nausea, retching, vomiting. To T1-T6 (1 day before chemotherapy - 4th day after chemotherapy))
- Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (CINV-dependent quality of life (QoL) at T0 (baseline), T6 (4th day after chemotherapy))
- Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (Cannabinoid-related toxicity with CannTox … Cannabinoid-related toxicity with CannTox module (based on the Drug Reaction Scale of adjectives describing mood, physical feelings, and perceptions of mental or cognitive functions of healthy volunteers under the influence of cannabis);</br>measured twice a weekluence of cannabis); measured twice a week)