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- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (Correlation of low- baseline vitamin D levels with development of aromatase inhibitor-induced arthralgia)
- Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Cumulative incidence of HFS)
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (DFS Randomization until secondary tumors or recurrence and 5-year DFS)
- Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (Daily life activity exposure levels)
- Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Defined as myocardial infarction, cerebrovascular accident, pulmonary embolism, deep vein thrombosis, and arterial thrombosis)
- Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Defined as the time from random assignment to a skeletal-related event or death from any cause, skeletal-related events were defined as pathologic bone fracture, spinal cord compression, surgery to the bone, or radiation to the bone)
- Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Degree of nausea Grade 0 defined as norma … Degree of nausea </br>Grade 0 defined as normal appetite; Grade 1 defined as loss of appetite without alteration in eating habits; Grade 2 defined as decreased oral intake without significant weight loss, dehydration, or malnutrition; Grade 3 defined as inadequate oral caloric or fluid intakeas inadequate oral caloric or fluid intake)
- Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (Delayed, anticipatory nausea)
- Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (Determine the effect of polyphenon E intervention on serum prostate-specific antigen (PSA).)
- Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (Dexamethasone)
- Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (Diarrhea)
- Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial + (Diarrhea)
- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Disease progression was observed in 63.8% of the patients, and death occurred in 53.4% of the patients treated during the 30 months of the study)
- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Disease progression was observed in 63.8% of the patients, and death occurred in 53.4% of the patients treated during the 30 months of the study)
- Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Disease response at the end of radiation (after 8 weeks))
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Disease-free 12-month survival:)
- Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (Disruption of daily activities due to fatigue with single item from the BFI)
- Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (Distortion product otoacoustic emissions (DPOAEs), average of the amplitude of the signal and signal-noise (S/N) ratio (SNR) Tested with Scout biologic equipment from bio-logic systems®)
- Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Dose reduction/Delay of chemotherapy)
- Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (Dry mouth, difficulty chewing / swallowing / speaking, burning sensation in the mouth, bad taste, waking up at night, prosthetic mesh, meeting people, talking to people, leaving the house)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Duration of fever)
- Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Duration of severe neutropenia)
- Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Duration of total parenteral nutrition)
- Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (Duration, severity and onset of oropharyngeal mucositis according to the dose of RT)
- Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (During 1 year)
- Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial + (During the first 2 years)
- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (During weekly visits patients underwent a … During weekly visits patients underwent a structured interview and physical examination by both a nurse and a radiation oncologist. At each visit, the following items were scored: pain control (Verbal descriptor scale).</br></br>Peak pain: </br></br>(0) None</br></br>(1) Slight </br></br>(2) Moderate </br></br>(3) Severe </br></br>(4) Extreme </br></br>(5) As bad as it can bere (4) Extreme (5) As bad as it can be)
- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (During weekly visits patients underwent a … During weekly visits patients underwent a structured interview and physical examination by both a nurse and a radiation oncologist. At each visit, the following items were scored: objective mucositis (CTCAE), functional mucositis (CTCAE) and dysphagia (CTCAE).l mucositis (CTCAE) and dysphagia (CTCAE).)
- Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (Dyspnea with a single item from the FACT-B other concerns subscale)
- Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (EE: excretion fraction; FUR: first-minute uptake ratio; MSP: maximum secretion percentage; MUR: maximum uptake ratio)
- Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (EORTC QLQC30 and EQ-5D<sub>index</sub>, and EQ-5D<sub>VAS</sub>)
- Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Effects on concurrent chemotherapy)
- Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (Efficiancy of supplementation)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (Electroneurographical tests/sensible nerve conduction studies of the median (upper extremities) and the sural nerve (lower extremities))
- Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Electrophysiological examination and evaluation of electrophysiology)
- Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Emergency medication)
- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Evaluation of acute toxicity was done by t … Evaluation of acute toxicity was done by the radiation oncologist together with the patient in an interview. Diarrhea was assessed by increase of stools per day. Vomiting was assessed by frequency per day. Nausea was assessed by decrease of food intake.The fatigue syndrome was assessed by loss of activity.syndrome was assessed by loss of activity.)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Evaluation of aromatherapy (odor, applicability, treatment effects))
- Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (Evidenced by any of the following three events: an increase in the HAQ-II score of 0.25 or more; an increase in CPIS score; or discontinuation of letrozole specifically due to aromatase inhibitor-associated musculoskeletal symptoms (AIMSS))
- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (Explorative endpoint)
- Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Extent of sleep disturbance)
- Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (Extent of sleep disturbance)
- Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Extent of sleep disturbance (assessed with NRS))
- Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Extent of sleep disturbance (assessed with NRS))
- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (FACT-F with 13 specific items to assess fatigue, which constitute the FACIT-F questionnaire)
- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (FACT-F, FACIT-HN, EORTCQLQ-30 & QLQ H&N35)
- Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (Fatigue at baseline and at 2h, 6h and 24h)
- Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (Fatigue severity)
- Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (Fatigue severity with single item from the BFI)
- Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (First occurrence of mucositis after start of radiation therapy)
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (Five-item questionnaire developed by the researchers who are trained in oncology nursing; were rated on a VNS of 0 to 10 (0´= being the healthiest attribute and 10 = being the worst) at day 1 and day 7)