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- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (During weekly visits patients underwent a … During weekly visits patients underwent a structured interview and physical examination by both a nurse and a radiation oncologist. At each visit, the following items were scored: pain control (Verbal descriptor scale).</br></br>Peak pain: </br></br>(0) None</br></br>(1) Slight </br></br>(2) Moderate </br></br>(3) Severe </br></br>(4) Extreme </br></br>(5) As bad as it can bere (4) Extreme (5) As bad as it can be)