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List of results

• Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia  + (Explorative endpoint)
• Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial  + (Extent of sleep disturbance)
• Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain  + (Extent of sleep disturbance)
• Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Extent of sleep disturbance (assessed with NRS))
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Extent of sleep disturbance (assessed with NRS))
• Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life  + (FACT-F with 13 specific items to assess fatigue, which constitute the FACIT-F questionnaire)
• Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life  + (FACT-F, FACIT-HN, EORTCQLQ-30 & QLQ H&N35)
• Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial  + (Fatigue at baseline and at 2h, 6h and 24h)
• Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients  + (Fatigue severity)
• Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer  + (Fatigue severity with single item from the BFI)
• Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen  + (First occurrence of mucositis after start of radiation therapy)
• Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study  + (Five-item questionnaire developed by the researchers who are trained in oncology nursing; were rated on a VNS of 0 to 10 (0´= being the healthiest attribute and 10 = being the worst) at day 1 and day 7)
• Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients  + (Frequency and severity)
• Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer  + (Frequency and severity of nausea and vomiting)
• Montazeri et al. (2013): Effect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients  + (Frequency and severity of nausea and vomiting)
• Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients  + (Frequency of development of greater than or equal to grade 2 pharyngitis)
• Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients  + (Frequency of development of greater than or equal to grade 2 oral mucositis)
• Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial  + (Frequency of postoperative rescue analgesics)
• Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer  + (Frequency of retching)
• Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer  + (Frequency of vomiting)
• Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study  + (Frequency of vomiting Vomiting was defined a disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.)
• Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study  + (Frequency, severity, clinical course, and consequences of HFS)
• Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial  + (From diagnosis to death)
• Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...)  + (From the day of randomization until death from any cause)
• Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients  + (Function Score)

• Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population?  + (Fundamental well-being)

• Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients  + (Further symptoms of the Symptom Inventory)
• Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients  + (General Health Score)
• Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (General intake, appropriate opioid intake for breakthrough pain and total opioid intake per day in morphine equivalents)
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (General intake, appropriate opioid intake for breakthrough pain and total opioid intake per day in morphine equivalents)
• Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain  + (General intake, intake for breakthrough pain and total opioid intake per day in morphine equivalents)
• Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy  + (Global Chalder Fatigue Scale: Measure of fatigue severity for both physical and mental symptoms that scored in a Likert format with response options ranging from better than usual to much worse than usual, with total possible score of 26.)
• Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial  + (Global cancer-associated quality of life (FACT-G). For T0 (Baseline) and T6 (4th day after chemotherapy))
• Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck  + (Grade 3 or 4)
• Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...)  + (Grade 3, 4 neutropenia or death within the first 30 days of treatment)
• Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy  + (Grade of neurotoxicity with FACT-NTX score)
• Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients  + (Grade of radiotherapy-associated side effects: Xerostomia, stomatitis, ageusia, and dysphagia)
• Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial  + (Graft-versus-host disease is a condition where the donated stem cells (graft) attack the recipient's body (host))
• Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy  + (Green tea and black tea polyphenol analysi … Green tea and black tea polyphenol analysis in prostate tissue and urine: </br>Three hundred milligrams of fresh frozen prostate tissue was homogenized and treated with 1,000 units of bglucuronidase and 40 units of sulfatase at 37 °C for 45 min. Solid phase extraction (SPE) was performed using preconditioned HLB cartridges and tea polyphenols</br>quantified by HPLC-CoulArray electrochemical detection. The detection limit was 0.2 pmol/g tissue.The detection limit was 0.2 pmol/g tissue.)
• Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT  + (Hand grip, lower body strength, physical performance)
• Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy  + (Health-related quality of life (day 1, 22, 23, and 64 of treatment))
• Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors  + (Hot Flashes)
• Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial  + (Hunger/appetite and craving for sweets and starchy products)
• Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients  + (INVR: Subscale of distress development)
• Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients  + (INVR: Subscale of symptom development)
• Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy  + (Improvement by ≥1 grade according to NCI-CTC criteria)
• Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial  + (Incidence and duration)
• Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial  + (Incidence and intensity of acute CINV)
• Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial  + (Incidence and intensity of delayed CINV)
• Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study  + (Incidence and severity)
• Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin  + (Incidence of anticipatory nausea (day 21/27) (VAS score>5mm), incidence of significant anticipatory nausea (VAS score>25mm))