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- Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (Serum-PSA-Level evaluated by high performance liquid chromatography and ELISA analysis)
- Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Severity (Rhodes Index Scores) of Nausea, Vomiting, and Retching)
- Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Severity of nausea at T1 (acute) and T2 (delayed) (0-10, 0 = none, 10 = strongest possible nausea) Nausea was defined a disorder characterized by a queasy sensation and/or the urge to vomit)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Severity of nausea, incidence of vomiting ( day 1 of chemotherapy to day 5 of chemotherapy))
- Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Severity of radiodermatitis (skin measurements weekly after the 5th radiationtherapy session))
- Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Severity, duration and commencement of radiotherapy induced mucositis)
- Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy + (Severity: FLIE mild = ≤6; moderate = 7-12; … Severity: FLIE</br>mild = ≤6;</br>moderate = 7-12;</br>severe = 13-15</br></br>Frequency: Diary entries</br>All participants recorded daily in a diary (number, consistency of stools, occurrence of symptoms such as nausea, vomiting and gastrointestinal cramps) from day 1 of the 2nd week to the end of the 5th weekof the 2nd week to the end of the 5th week)
- Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Short forms of the PROMIS: Scale for physical functioning (study weeks 3, 5, 11))
- Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Side effects)
- Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Side effects (continuous until 30 days after last intervention))
- Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Side effects included diarrhea, constipation, heartburn.)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Skin toxicity)
- Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Sleep quality)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Sleep quality and mood (no information on survey))
- Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Specific questionnaires were used: FACIT- … Specific questionnaires were used: </br>FACIT-F that assesses self-reported QOL and fatigue with total score ranging from 0 to 160 </br>FACIT-ES that includes a subspace evaluating menopausal symptoms, among other components that are totaled to provide an overall score ranging from 0 to 180ide an overall score ranging from 0 to 180)
- Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer + (Specific results for: a) age of death b) stratification with regard to smoking history (less than 25 pack/year vs. more than 25 pack/year c) stratification with regard to plasma beta-carotene)
- Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Specifically tumor clearance, i.e. the proportion of patients with complete histological tumor clearance after eight weeks (time point 3))
- Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Specifically tumor size, examination after three weeks (time point 1), six weeks (time point 2) and eight weeks (time point 3))
- Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (Specification NRS: Constipation NRS)
- Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Specification NRS: constipation NRS)
- Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Specification NRS: constipation NRS)
- Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (Specification of type of measurement: EORTC QLQ-OES18 (Oesophageal module))
- Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Specified type of measurement: FACT-G (General))
- Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (Start of sensory neuropathy)
- Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Study week 3,5,11)
- Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9 + (Subjective)
- Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Subjective Objective Medical management and Analytic evaluation of injury (SOMA)-Score: T1und T2)
- Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Summarized scale for restrictions of daily life (study week 1-4, 5, 11))
- Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Summarized scale for symptom severity (study weeks 1-4, 5, 11))
- Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Surface reduction of fibrosis (after 3 months))
- Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Surface reduction of fibrosis (after 6 months))
- Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Survival rate)
- Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial + (Symptom experience diary questionnaire developed by NCCTG, range 0-70, peripheral neuropathy, if absolute value > 0)
- Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Syndrome may resemble arthritis, but may also mimic fibromyalg)
- Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T2-weighted magnetic resonance imaging (MRI) after therapy compared with volume at baseline)
- Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T2-weighted magnetic resonance imaging (MRI) after therapy compared with volume at baseline)
- Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T2-weighted magnetic resonance imaging (MRI) after therapy compared with volume at baseline)
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (Taking a picture using a digital camera on day 1 and day 7; provides an objective assessment of the healing progress of the wound in term of its size, type and amount of necrotic tissues, and amount of exudates)
- Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (Taste acuity (detection and recognition) for four taste qualities (salty, sweet, sour, and bitter))
- Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (Taste acuity: detection and recognition thresholds for four taste qualities (sweet, salty, sour, and bitter))
- Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (The clinical response and toxicity were as … The clinical response and toxicity were assessed according to WHO criteria. The clinical responses were radiologically evaluated after at least three cycles of chemotherapy by repeating the same radiological investigation used prior to the onset of chemotherapy, including CT scan, NMR and PET. </br></br></br>Gradations: </br></br>Complete response</br></br>Partial response</br></br>Stable disease</br></br>Disease control</br></br>Progressive diseaseease Disease control Progressive disease)
- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (The clinical response was evaluated according to WHO criteria, by repeating the radiological examinations at 2-month intervals. WHO Gradiations: Complete response Partial response Stable disease Disease control Progressive disease)
- Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (The date of the first treatment to local recurrence or distant metastases)
- Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (The effect of radiation-induced symptoms o … The effect of radiation-induced symptoms on lifestyle</br></br>Grade</br>0 = Symptoms cause no effect on daily activity</br></br>1 = Symptoms cause inconveniences at least once a week</br></br>2 = Symptoms interfere with day-to-day activities more than once a week</br></br>3 = Symptoms interfere with routine activities on a daily basis</br></br>4 = Afraid to leave home with significant restriction in social lifeith significant restriction in social life)
- Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (The patients were asked to report their pain intensity by VAS, a 10cm ruler in which zero shows no pain and 10 represents intolerable pain.)
- Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (The patients’ mouths were examined for sto … The patients’ mouths were examined for stomatitis by two assistants on days 1, 3, 5, 7, and 14 with WHO stomatitis intensity survey checklist:</br></br>0 = no stomatitis</br></br>1 = represents pain and erythema without wounds</br></br>2 = refers to the case where wound and erythema exist, but the patient is able to eat solid food</br></br>3 = is existence of extensive wound and erythema and inability to eat solid food</br></br>4 = mucosal bleeding, extensive inflammation, and complete inability to eat and drinkn, and complete inability to eat and drink)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (The period between the time of treatment and the time of death; Subgroup analysis: no significant difference between the arms for the 5-year OS among the patients with stages III to IV head and neck cancers other than nasopharyngeal carcinoma (p = .357))
- Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Therapy result 5-6 months after completion of radiotherapy (at Follow-up 3))
- Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Time between random assignment and death, regardless of cause)
- Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (Time between surgical treatment and recurrence of detectable disease)
- Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Time from radiation therapy initiation to lethal prostate cancer (death from prostate cancer or participant-reported bone metastases among living participants))