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List of results

Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Survival rate)
Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial + (Symptom experience diary questionnaire developed by NCCTG, range 0-70, peripheral neuropathy, if absolute value > 0)
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Syndrome may resemble arthritis, but may also mimic fibromyalg)
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T2-weighted magnetic resonance imaging (MRI) after therapy compared with volume at baseline)
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T2-weighted magnetic resonance imaging (MRI) after therapy compared with volume at baseline)
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T2-weighted magnetic resonance imaging (MRI) after therapy compared with volume at baseline)
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (Taking a picture using a digital camera on day 1 and day 7; provides an objective assessment of the healing progress of the wound in term of its size, type and amount of necrotic tissues, and amount of exudates)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (Taste acuity (detection and recognition) for four taste qualities (salty, sweet, sour, and bitter))
Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (Taste acuity: detection and recognition thresholds for four taste qualities (sweet, salty, sour, and bitter))
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (The clinical response and toxicity were as … The clinical response and toxicity were assessed according to WHO criteria. The clinical responses were radiologically evaluated after at least three cycles of chemotherapy by repeating the same radiological investigation used prior to the onset of chemotherapy, including CT scan, NMR and PET. Gradations: Complete responsePartial responseStable diseaseDisease controlProgressive diseaseease Disease control Progressive disease)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (The clinical response was evaluated according to WHO criteria, by repeating the radiological examinations at 2-month intervals. WHO Gradiations: Complete response Partial response Stable disease Disease control Progressive disease)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (The date of the first treatment to local recurrence or distant metastases)
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (The effect of radiation-induced symptoms o … The effect of radiation-induced symptoms on lifestyleGrade0 = Symptoms cause no effect on daily activity1 = Symptoms cause inconveniences at least once a week2 = Symptoms interfere with day-to-day activities more than once a week3 = Symptoms interfere with routine activities on a daily basis4 = Afraid to leave home with significant restriction in social lifeith significant restriction in social life)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (The patients were asked to report their pain intensity by VAS, a 10cm ruler in which zero shows no pain and 10 represents intolerable pain.)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (The patients’ mouths were examined for sto … The patients’ mouths were examined for stomatitis by two assistants on days 1, 3, 5, 7, and 14 with WHO stomatitis intensity survey checklist:0 = no stomatitis1 = represents pain and erythema without wounds2 = refers to the case where wound and erythema exist, but the patient is able to eat solid food3 = is existence of extensive wound and erythema and inability to eat solid food4 = mucosal bleeding, extensive inflammation, and complete inability to eat and drinkn, and complete inability to eat and drink)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (The period between the time of treatment and the time of death; Subgroup analysis: no significant difference between the arms for the 5-year OS among the patients with stages III to IV head and neck cancers other than nasopharyngeal carcinoma (p = .357))
Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Therapy result 5-6 months after completion of radiotherapy (at Follow-up 3))
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Time between random assignment and death, regardless of cause)
Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (Time between surgical treatment and recurrence of detectable disease)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Time from radiation therapy initiation to lethal prostate cancer (death from prostate cancer or participant-reported bone metastases among living participants))
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (Time from randomization to disease progression (radiographic progression) or death from any cause)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Time from the first day of treatment to death)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Time from the start of chemotherapy and vitamin D3 to first occurrence of documented disease progression or death)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Time from the start of treatment to any cause of death)
Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (Time of serum 25OHD levels and percentage of patients that reached the 25OHD cut-off level of sufficiency (>30 ng/mL from August to November and >20 ng/mL from January to July) during the 1st year)

Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (Time period over 4 years)

Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Time to HFS (CTCAE grade ≥ 2))
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (Time to progression)
Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Time to second primary tumor (SPT))
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Total daily physical activity and the asso … Total daily physical activity and the associated energy expenditureSenseWear PRO2 wristband: able to assess total energy expenditure (TEE), that is, the sum of REE plus the energy spent in physical activity (active energy expenditure [AEE]), which is able to identify the specific type of physical activity (e.g., walking, running, lying down) in such a wayastoattribute to it a “functional quality”n such a wayastoattribute to it a “functional quality”)
Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Total number of positive cystoscopies in the group/total number of follow-up years in the group)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Toxicity)
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (Toxicity of chemotherapy Components of Peripheral Neuropathy (according to CTCAE 4.02): sensory, motor, and pain Data collection points: Start with the first chemotherapy cycle, before each cycle, and then monthly)
Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Toxicity of chemotherapy: incidence of hand-foot syndrome (HFS) according to CTCAE (last follow-up: 4th chemotherapy cycle, i.e. after 4-6 months))
Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Toxicity of chemotherapy: necessary reduction of the capecitabine dose)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Toxicity of nabilone)
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Toxicity was assessed according to WHO criteria. Patients were monitored weekly by routine laboratory tests. The evaluation of subjective symptoms, such as fatigue and asthenia, was assessed by an individual report.)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Transplantation to discharge)
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Treatment interruption (in days) or premature end of radiation therapy due to radiation-induced side effects)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (Trial Outcome Index (TOI) from the FACT-B at Baseline end-point 1 (week 18 post surgery).)
Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Tumor progression)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Tumor response rate)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Usage of Hydrocortison)
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Vaginal atrophy, pH, and vaginal maturation index)
Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (Vitagramm: 4 qualities of life: 1. employable or able to work, free of complaints 2. care-free, only minor complaints 3. in need of care, more severe symptoms 4. bedridden and/or very severe discomfort)
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Volume reduction)
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study + (Vomiting frequency (divided into: no vomiting=complete control, 1-2x=partial control, ≥3=no control))
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (Vomiting severity)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Weight fluctuations, total days without feeding tube or gastrostomy)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Weight gain (10% of own weight))
Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial + (Weight loss)