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- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (T0: Baseline (3 days before starting radiotherapy) T1: day 3 of radiation T2: day 8 of radiation T3: day 15 of radiation T4: day 21 of radiation T5: day 28 of radiation T6: day 35 of radiation)