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- Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (T0: Baseline T1: after 3 weeks T2: after 6 weeks T3: after 8 weeks (directly before operation))
- Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy + (T0: Baseline T1: after 3. chemotherapy cycle T2: 1 month post-chemotherapy)
- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (T0: Baseline T1: after 4 weeks (first phase) T2: after 8 weeks (second phase))
- Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors + (T0: Baseline T1: after 6 month)
- Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (T0: Baseline T1: after 6 months of chemotherapy)
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (T0: Baseline T1: after 7 days)
- Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (T0: Baseline T1: after an average of 3 to 6 weeks until the operation)
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (T0: Baseline T1: after at least 6 weeks)
- Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis + (T0: Baseline T1: after first cycle T2: after second cycle T3: after third cycle T4: after fourth cycle)
- Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer + (T0: Baseline T1: after three years)
- Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (T0: Baseline T1: at the end of radiotherapy Follow-Up: a month later)
- Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (T0: Baseline T1: at week 12 T2: at week 24)
- Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (T0: Baseline T1: weekly for 8 weeks during radiation Follow up 1: 6-8 weeks after end of radiation Follow-up 2: 2-3 month after end of radiation Follow-up 3: 5-6 month after end of radiation)
- Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (T0: Baseline T1: weekly until progression of diasease Follow-up: after 3 years)
- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (T0: Baseline T1: weekly visits for 6 weeks)
- Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (T0: Baseline T1: Week 4 T2: Week 7 during treatment T3: Week 6-8 post-treatment T4: Follow-up 3 months after completion of the study and then at further 3-month intervals over 2 years, then every 6 months until 5 years thereafter)
- Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (T0: Baseline T1-T3: Tag 7, 14, 21)
- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (T0: Baseline T1: After 3 weeks T2: After 6 weeks T3: After 9 weeks)
- Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (T0: Baseline T1: End of study)
- Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (T0: Baseline T1: after 3 months of chemotherapy T2: after 6 months of chemotherapy)
- Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (T0: Baseline T1: day 9 T2: day 19 T3: day 45)
- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (T0: Baseline (3 days before starting radiotherapy) T1: day 3 of radiation T2: day 8 of radiation T3: day 15 of radiation T4: day 21 of radiation T5: day 28 of radiation T6: day 35 of radiation)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (T0: Baseline (before chemotherapy) T1: Day 1 (day of chemotherapy) T2: Day 2 T3: Day 3 T4: Day 4 T5: Day 5 T6: Day 8)
- Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (T0: Baseline (before chemotherapy) T1: after 2 weeks T2: after 4 weeks T3: after 6 weeks T4: after 8 weeks T5: after 10 weeks T6: after 12 weeks T7: after 14 weeks T8: after 16 weeks T9: after 18 weeks T10: after 20 weeks)
- Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (T0: Baseline (before intervention) T1: 4 weeks T2: 8 weeks T3: 12 weeks after the start of the intervention)
- Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (T0: Baseline (before radiojodtherapy) T1: 6 months after radiojodtherapy)
- Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (T0: Baseline (pre-/peri-op) T1: 2h post-op T2: 6h post-op T3: 24h post-op)
- Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (T0: Baseline (prior to chemotherapy) T1: 3 months after chemotherapy)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (T0: Baseline (start of chemotherapy) T1: End of chemotherapy (6 days) T2: +1 day: transplantation T3: 21 days after transplantation T4: Follow-up after 3 months)
- Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (T0: Baseline (week 1) T1: Week 2 T2: Week 3 T3: Week 4)
- Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (T0: Baseline = 10 days prior to the first day of radiation therapy T1: weekly for 3-4 weeks Follow-up: 8th week)
- Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T0: Baseline at the beginning of radiotherapy, T1: At the end of radiotherapy, Follow-up: After 4 weeks end of radiotherapy)
- Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (T0: Baseline before intervention T1: 6 weeks after intervention T2: 12 weeks after intervention)
- Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (T0: Baseline before radiation T1: first week of radiation T2: third week of radiation T3: sixth week of radiation)
- Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (T0: Baseline one week before radiation T1: 1 week after start of radiation T2: 2 weeks after start of radiation T3: 3 weeks after start of radiation T4: 4 weeks after start of radiation T5: 5 weeks after start of radiation (=end of radiation))
- Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (T0: Baseline proir to first radiation T1: weekly until the end of radiation)
- Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (T0: Baseline visit prior to radiation T2-T7: weekly visits during 6 weeks of radiation Follow-up: one week after the end of radiaton)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (T0: Baseline, Day 0 of therapy T1: Day 21, i.e. directly after treatment T2: Follow-up, day 84 after treatment)
- Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (T0: Baseline, after surgery T1: After 5 weeks)
- Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (T0: Baseline, chemotherapy T1: After 3 weeks (after induction) T2: After 6 weeks (maintenance phase))
- Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (T0: Basline T1: after 1.5 months T2: after 3 months T3: after 6 months)
- Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (T0: Day -3 to -1: before the chemotherapy T1: Day 1: first day of chemotherapy T2: Day 2 to 4: after chemotherapy)
- Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (T0: Day 0, immediately before the first radiation treatment T1: Day 14, switching phase T2: Day 28, right before the start of the last radiation treatment)
- Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (T0: Day 2 surgery T1-T3: Day 2-4 post surgery; Follow up: Day 5, Day 6 surgery)
- Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (T0: Early morning, 7-7:30 am; T1: mid morning, 11-11:30 am; T2: Early afternoon, 1-1:30 pm; T3: late afternoon, 4-4:30 pm)
- Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (T0: Week -1 Vitamin E (measured for 1 week) T1: after 4 weeks T2: after 8 weeks)
- Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (T0: after radiotherapy Follow-Up: every 3 months after therapy)
- Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (T0: baseline Every month for the first 6 … T0: baseline</br></br>Every month for the first 6 months</br></br>Every 2 months for the second 6 months</br></br>Every 3 months thereafter until 5 years</br></br>After 5 years, follow-up continued to occur every 3 to 6 months depending on a patient’s condition as judged by the surgeon in chargendition as judged by the surgeon in charge)
- Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (T0: baseline T1: after 2 weeks T2: after 4 weeks T3: after 6 weeks)
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (T0: baseline T1: after 3 months T2: after 6 months T3: after 9 months T4: after 12 months)
- Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (T0: baseline T1: after 3 weeks (21 days) T2: after 5 weeks (35 days) T3: after 7 weeks follow-up (up to day 43))