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- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (T0: Baseline (3 days before starting radiotherapy) T1: day 3 of radiation T2: day 8 of radiation T3: day 15 of radiation T4: day 21 of radiation T5: day 28 of radiation T6: day 35 of radiation)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (T0: Baseline (before chemotherapy) T1: Day 1 (day of chemotherapy) T2: Day 2 T3: Day 3 T4: Day 4 T5: Day 5 T6: Day 8)
- Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (T0: Baseline (before chemotherapy) T1: after 2 weeks T2: after 4 weeks T3: after 6 weeks T4: after 8 weeks T5: after 10 weeks T6: after 12 weeks T7: after 14 weeks T8: after 16 weeks T9: after 18 weeks T10: after 20 weeks)
- Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (T0: Baseline (before intervention) T1: 4 weeks T2: 8 weeks T3: 12 weeks after the start of the intervention)
- Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (T0: Baseline (before radiojodtherapy) T1: 6 months after radiojodtherapy)
- Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (T0: Baseline (pre-/peri-op) T1: 2h post-op T2: 6h post-op T3: 24h post-op)
- Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (T0: Baseline (prior to chemotherapy) T1: 3 months after chemotherapy)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (T0: Baseline (start of chemotherapy) T1: End of chemotherapy (6 days) T2: +1 day: transplantation T3: 21 days after transplantation T4: Follow-up after 3 months)
- Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (T0: Baseline (week 1) T1: Week 2 T2: Week 3 T3: Week 4)
- Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (T0: Baseline = 10 days prior to the first day of radiation therapy T1: weekly for 3-4 weeks Follow-up: 8th week)
- Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (T0: Baseline at the beginning of radiotherapy, T1: At the end of radiotherapy, Follow-up: After 4 weeks end of radiotherapy)
- Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (T0: Baseline before intervention T1: 6 weeks after intervention T2: 12 weeks after intervention)
- Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (T0: Baseline before radiation T1: first week of radiation T2: third week of radiation T3: sixth week of radiation)
- Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (T0: Baseline one week before radiation T1: 1 week after start of radiation T2: 2 weeks after start of radiation T3: 3 weeks after start of radiation T4: 4 weeks after start of radiation T5: 5 weeks after start of radiation (=end of radiation))
- Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (T0: Baseline proir to first radiation T1: weekly until the end of radiation)
- Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (T0: Baseline visit prior to radiation T2-T7: weekly visits during 6 weeks of radiation Follow-up: one week after the end of radiaton)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (T0: Baseline, Day 0 of therapy T1: Day 21, i.e. directly after treatment T2: Follow-up, day 84 after treatment)
- Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (T0: Baseline, after surgery T1: After 5 weeks)
- Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (T0: Baseline, chemotherapy T1: After 3 weeks (after induction) T2: After 6 weeks (maintenance phase))
- Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (T0: Basline T1: after 1.5 months T2: after 3 months T3: after 6 months)
- Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (T0: Day -3 to -1: before the chemotherapy T1: Day 1: first day of chemotherapy T2: Day 2 to 4: after chemotherapy)
- Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (T0: Day 0, immediately before the first radiation treatment T1: Day 14, switching phase T2: Day 28, right before the start of the last radiation treatment)
- Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (T0: Day 2 surgery T1-T3: Day 2-4 post surgery; Follow up: Day 5, Day 6 surgery)
- Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (T0: Early morning, 7-7:30 am; T1: mid morning, 11-11:30 am; T2: Early afternoon, 1-1:30 pm; T3: late afternoon, 4-4:30 pm)
- Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (T0: Week -1 Vitamin E (measured for 1 week) T1: after 4 weeks T2: after 8 weeks)
- Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (T0: after radiotherapy Follow-Up: every 3 months after therapy)
- Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (T0: baseline Every month for the first 6 … T0: baseline</br></br>Every month for the first 6 months</br></br>Every 2 months for the second 6 months</br></br>Every 3 months thereafter until 5 years</br></br>After 5 years, follow-up continued to occur every 3 to 6 months depending on a patient’s condition as judged by the surgeon in chargendition as judged by the surgeon in charge)
- Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (T0: baseline T1: after 2 weeks T2: after 4 weeks T3: after 6 weeks)
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (T0: baseline T1: after 3 months T2: after 6 months T3: after 9 months T4: after 12 months)
- Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (T0: baseline T1: after 3 weeks (21 days) T2: after 5 weeks (35 days) T3: after 7 weeks follow-up (up to day 43))
- Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (T0: baseline T1: after 3 weeks (day 22) T2: after 5 weeks (day 36) Follow-up: after 7 weeks (up to day 43))
- Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (T0: baseline T1: after 3 weeks (day 22) T2: after 5 weeks (day 36) Follow-up: after 7 weeks (up to day 43))
- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (T0: baseline T1: 2-month-intervals until progression of diasease Follow-up: after 1 year)
- Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (T0: baseline T1: after 12 weeks T2: after 24 weeks T3: after 36 weeks T4: after 52 weeks T5: after 104 weeks)
- Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (T0: baseline T1: after 3 months T2: after 6 months)
- Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (T0: baseline T1: end of study (no clear end of study defined))
- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (T0: baseline T1: week 12 T2: week 52)
- Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (T0: baseline T1: week 2 T2: week 4 T3: week 8)
- Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (T0: baseline T1: one day before chemotherapy T2: day 8 of each cycle T3: between 30-42 days after end of intervention)
- Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (T0: baseline T1: weekly until end of radiation T2: week 1, 2, and 4 after end of radiation)
- Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (T0: baseline (2 days) T1: after 7-10 days T2: after 14-20 days)
- Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (T0: baseline (day 0: allocation) T1: after 15 days T2: after 30 days T3: after 180 days T4: after 365 days Follow-up: 2 years)
- Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (T0: baseline = day 1 of radiation treatment T1: weekly throughout radiation treatment Follow-up: 2 weeks after treatment)
- Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (T0: baseline before first cycle of chemotherapy afterwards: observation over 2 years or until death)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (T0: baseline before radiotherapy T1: first week T2: second week until T3: 7<sup>th</sup> week Follow-up: between 9<sup>th</sup> - 11<sup>th</sup> week)
- Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (T0: baseline before the beginning of supplementation T1-T4: before each of the four cycles of chemotherapy)
- Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (T0: basline T1: after cycle 4 of chemotherapy (8 weeks) T2: after cycle 8 of chemotherapy (16 weeks) Follow-Up (End of study))
- Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (T0: basline T1: after cycle 4 of chemotherapy (8 weeks) T2: after cycle 8 of chemotherapy (16 weeks) Follow-Up)
- Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (T0: basline T1: week 12 T2: week 24)
- Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study + (T0: before intervention (baseline) T1: 2 weeks (end of phase 1) T2: 1 week after the start of the intervention T3: 4 weeks (end of phase 2))
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (T0: before operation T1-T3: on day 1-3 after operation T4: on day 5 after operation)