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- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + ('''Survival rate after 12 months ''' The percent 1-year survival achieved in patients of the aloe arm was also significantly higher than that seen in the control arm: Aloe arm = 9/24 (37%); Control arm = 4/26 (15%) (p<0.05).)