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- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (Although the maximum extent of gastrointes … Although the maximum extent of gastrointestinal side effects was reduced in the enzyme-arm, the difference to the control-arm was not statistically significant (p=0.12). The treatment effect was observed from 1 week after start of radiation therapy until the last follow-up visit 5 month after intervention.ollow-up visit 5 month after intervention.)