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- Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (Mean Volometer of the ill arm at day 45: Enzyme-arm = 2275.1; Placebo-arm = 2225.7 Both arms show a decrease of volume until day 45, but there was no significant difference between the arms (p = NI).)