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List of results

Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (No difference between the treatment arms was found among the arms in the Likert scales measuring the change in the symptoms comparedwith the previous week.)
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (No differences between the groups during irradiation (boswellia: 0-84mg/week; placebo: 0-112mg/week))
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (No radiation-related headaches and ulcerat … No radiation-related headaches and ulcerations occurred in either arm; vomiting symptoms and oedema only occurred in the control-arm; all other symptoms occurred in both arms, but less frequently and less intensively in the enzyme-arm than in the control-arm.Deterioration of the general status in 5.5% of the enzyme-arm and in 11.4% of the control-arm, no changes of the general status in 94.5% of the enzyme-arm and 88.6% of the control-arm.e enzyme-arm and 88.6% of the control-arm.)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (No sig. difference between the arms (reflexology arm/control arm: ß= -0.335 [3.81]; p=0.38, reflexology arm/foot massage: NI).)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (No sig. differences between the arms (reflexology arm/control arm: 0.387 [2.194]; p= 0.86, reflexology arm/control arm: NI))
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (No sig. differences between the arms (reflexology arm/control arm: ß= -0.487 [1.21]; p=0.69; reflexology arm/foot massage arm: NI))
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (No sig. differences between the arms (reflexology arm/control arm: ß= -2.87 [0.389]; p=0.46; reflexology arm/foot massage arm: NI))
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (No sig. differences between the arms (reflexology arm/control arm: ß= -2.87 [0.389]; p=0.46; reflexology arm/foot massage arm: NI))
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (No sig. differences between the arms (reflexology arm/control arm: β=0.212[0.124], p=0.089, reflexology arm/foot massage arm: NI))
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (No sig. differences between the arms (reflexology arm/control arm: ß= -0.886 [1.259]; p=0.48; reflexology arm/foot massage arm: NI))
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (No sig. differences between the arms (β= 0.195 [0.67]; p=0.77))
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (No sig. differences between the arms (β= 0.599 [0.36]; p=0.10))
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (No sig. differences between the arms (β= 1.659 [0.88]; p=0.06))
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (No sign. difference between arms (p=NI))
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (No sign. differences according to grade (no values given, only graph and p-values): grade 1: p = 0.31, grade 2: p = 0.25, grade: 3: p = 0.93, grade 4: p = 0.32 Mean length: no significant difference seperated by diagnosis (ALL, CML, AML).)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (No significant arm difference (p=0.414-0.959))
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significant arm differences after 7 weeks (p=0.9328).)
Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (No significant arm differences in the mean … No significant arm differences in the mean PSA doubling time (intervention arm 21 months vs. control arm 15 months; p=0.446, not significant)Post hoc analysis: after adjustment for key demographic variables and PSA levels possibly reduced by weight loss and associated altered hemoconcentration measurement: slowed PSA doubling in intervention arm compared to control arm; however, questionableared to control arm; however, questionable)
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (No significant between the arms were found. Arm intervention-placebo: After day 14: p = 0.52 Arm placebo-intervention: After day 14: p = 0.15 Comparison between both arms: Phase 1: p = . 24 Phase 2: p = .37 Phase 3: p = .39)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (No significant difference (123 vs. 141 vs. 113 days) between the Megestrol Acetate versus Dronabinol versus the combination arm, respectively (log Rank p=0.66))
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (No significant difference between arms (p=0.55))
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant difference between the 2 arms; no further information given)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (No significant difference between the arms. Comparison between the Placebo and Intervention Arm: After Day 42: HADS A: p = .75, HADS D: p = .94)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (No significant difference between the arms. Comparison between the Placebo and Intervention Arm: After Day 42: p = .75)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (No significant difference between the arms. Comparison between the Placebo and Intervention Arm: After Day 42: p = .81)

Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (No significant difference between the arms (p= 0.408))

Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (No significant difference between the arms (p= 0.489))
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (No significant difference for week 6-8 post-treatment and Follow-up within a year)
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (No significant difference regarding the absolute duration of neutropenia (p = 1); no significant difference seperated by diagnosis)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (No significant difference was found between the two arms with respect to the mean intensity of stomatitis and pain on day 1, but a significant difference was observed in this regard on days 3 to 14.)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (No significant difference was found between the two arms with respect to the mean intensity of stomatitis and pain on day 1, but a significant difference was observed in this regard on days 3 to 14.)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (No significant differences)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (No significant differences between intervention and placebo arm)
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (No significant differences between the arms were found. Arm intervention-placebo: After day 14: p = 0.51 Arm placebo-intervention: After day 14: p = 0.49 Comparison between both arms: Phase 1: p = .99 Phase 2: p = .97 Phase 3: p = .75)
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant differences in disease-free survival between the placebo and guarana arm (p=0.363, only graphically displayed).)
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant differences in overall survival between the placebo and guarana arm (p=0.498, only graphically displayed).)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (No significant differences in overall survival)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (No significant differences in progression-free survival)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (No significant differences regarding general health status and the 5 dimensions of the questionnaire used (mobility, self-care, usual activities, pain, anxiety/depression (numbers not given, only graphs))
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant differences were observed between the placebo and guarana arms.)
Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients + (No significant differences; overall number of serious adverse events, not significantly different: intervention arm 23x and control arm 22x (p=0.476))
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (No significant group differences for nausea: ginger vs. placebo: 60.6% vs. 72.5% (p=0.214), vomiting: ginger vs. placebo: 22.5% vs. 26.1% (p=0.813), in mean nausea scores (p=0.347) and frequency of vomiting (p=0.71))
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (No statistically significant difference was found in this confirmative analysis between the enzyme-arm and the placebo-arm (p=0.317). Grade distributions as well as average scores were virtually identical.)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (No statistically significant difference in weight loss between the two arms 1 month after radiotherapy)
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (No statistically significant differences in mucositis grade were found between the two mouthwashes (p = 0.35).)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (No statistically significant differences w … No statistically significant differences were found in the symptoms of dryness, itching, or burning among the 3 arms at 1 week after radiotherapy.A statistically significant difference was found in the pain scores, with 9 of the 67 powder arm patients rating pain as high compared with 21 of 72 in the aloe arm and 25 of the 74 in the placebo arm (p=0.0163).5 of the 74 in the placebo arm (p=0.0163).)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (No study-treatment-related adverse events … No study-treatment-related adverse events were observed; No significant difference in the incidence of adverse events between subjects receiving ginger and placebo.Side effects - Intervention in n: Fever: n = 4, Fatigue: n = 25, Muscosites: n = 5, Diarrhea: n = 2, Constipation: n = 14, Neutropenia: n = 6, Thrombcytopenia: n = 14 Side effects - Placebo in n: Fever: n = 3, Fatigue: n = 21, Mucositis: n = 4, Constipation: n = 12, Neutropenia: n = 4, Thrombcytopenia: n = 12, Febrile neutropenia: n = 1no significant differencestropenia: n = 1 no significant differences)
Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis + (Number in % with grade 3-4 After 4th cycle intervention arm (paste): 26.3, intervention arm (tablets): 43.7, placebo arm: 42.8; p = 0.01)
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (Number of CR/PR/PD/SD/NA: no significant difference between arms (lycopene: 10/10/3/1/1, placebo: 5/6/8/1/5; p = 0.100, not significant))
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (Number of patients ITT: not reported PP: intervention arm: A: grade 0: 13/16; grade 1: 2/16, grade 2: 1/16; control arm: grade 0: 6/16; grade 1: 5/16, grade 2: 4/16; grade 4: 1/16)
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Number of patients: ITT: not reported PP: intervention arm: grade 0: 13/14; grade 1: 1/14; control arm: grade 0: 8/16; grade 1: 5/16, grade 2: 2/16; grade 4: 1/16)