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- Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (No significant differences between the arms were found. Arm intervention-placebo: After day 14: p = 0.51 Arm placebo-intervention: After day 14: p = 0.49 Comparison between both arms: Phase 1: p = .99 Phase 2: p = .97 Phase 3: p = .75)