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List of results

Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (No sig. differences between the arms (β= 1.659 [0.88]; p=0.06))
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (No sign. difference between arms (p=NI))
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (No sign. differences according to grade (no values given, only graph and p-values): grade 1: p = 0.31, grade 2: p = 0.25, grade: 3: p = 0.93, grade 4: p = 0.32 Mean length: no significant difference seperated by diagnosis (ALL, CML, AML).)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (No significant arm difference (p=0.414-0.959))
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significant arm differences after 7 weeks (p=0.9328).)
Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (No significant arm differences in the mean … No significant arm differences in the mean PSA doubling time (intervention arm 21 months vs. control arm 15 months; p=0.446, not significant)Post hoc analysis: after adjustment for key demographic variables and PSA levels possibly reduced by weight loss and associated altered hemoconcentration measurement: slowed PSA doubling in intervention arm compared to control arm; however, questionableared to control arm; however, questionable)
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (No significant between the arms were found. Arm intervention-placebo: After day 14: p = 0.52 Arm placebo-intervention: After day 14: p = 0.15 Comparison between both arms: Phase 1: p = . 24 Phase 2: p = .37 Phase 3: p = .39)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (No significant difference (123 vs. 141 vs. 113 days) between the Megestrol Acetate versus Dronabinol versus the combination arm, respectively (log Rank p=0.66))
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (No significant difference between arms (p=0.55))
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant difference between the 2 arms; no further information given)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (No significant difference between the arms. Comparison between the Placebo and Intervention Arm: After Day 42: HADS A: p = .75, HADS D: p = .94)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (No significant difference between the arms. Comparison between the Placebo and Intervention Arm: After Day 42: p = .75)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (No significant difference between the arms. Comparison between the Placebo and Intervention Arm: After Day 42: p = .81)
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (No significant difference between the arms (p= 0.408))
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (No significant difference between the arms (p= 0.489))
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (No significant difference for week 6-8 post-treatment and Follow-up within a year)
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (No significant difference regarding the absolute duration of neutropenia (p = 1); no significant difference seperated by diagnosis)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (No significant difference was found between the two arms with respect to the mean intensity of stomatitis and pain on day 1, but a significant difference was observed in this regard on days 3 to 14.)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (No significant difference was found between the two arms with respect to the mean intensity of stomatitis and pain on day 1, but a significant difference was observed in this regard on days 3 to 14.)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (No significant differences)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (No significant differences between intervention and placebo arm)
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (No significant differences between the arms were found. Arm intervention-placebo: After day 14: p = 0.51 Arm placebo-intervention: After day 14: p = 0.49 Comparison between both arms: Phase 1: p = .99 Phase 2: p = .97 Phase 3: p = .75)
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant differences in disease-free survival between the placebo and guarana arm (p=0.363, only graphically displayed).)
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant differences in overall survival between the placebo and guarana arm (p=0.498, only graphically displayed).)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (No significant differences in overall survival)

Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (No significant differences in progression-free survival)

Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (No significant differences regarding general health status and the 5 dimensions of the questionnaire used (mobility, self-care, usual activities, pain, anxiety/depression (numbers not given, only graphs))
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (No significant differences were observed between the placebo and guarana arms.)
Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients + (No significant differences; overall number of serious adverse events, not significantly different: intervention arm 23x and control arm 22x (p=0.476))
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (No significant group differences for nausea: ginger vs. placebo: 60.6% vs. 72.5% (p=0.214), vomiting: ginger vs. placebo: 22.5% vs. 26.1% (p=0.813), in mean nausea scores (p=0.347) and frequency of vomiting (p=0.71))
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (No statistically significant difference was found in this confirmative analysis between the enzyme-arm and the placebo-arm (p=0.317). Grade distributions as well as average scores were virtually identical.)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (No statistically significant difference in weight loss between the two arms 1 month after radiotherapy)
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (No statistically significant differences in mucositis grade were found between the two mouthwashes (p = 0.35).)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (No statistically significant differences w … No statistically significant differences were found in the symptoms of dryness, itching, or burning among the 3 arms at 1 week after radiotherapy.A statistically significant difference was found in the pain scores, with 9 of the 67 powder arm patients rating pain as high compared with 21 of 72 in the aloe arm and 25 of the 74 in the placebo arm (p=0.0163).5 of the 74 in the placebo arm (p=0.0163).)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (No study-treatment-related adverse events … No study-treatment-related adverse events were observed; No significant difference in the incidence of adverse events between subjects receiving ginger and placebo.Side effects - Intervention in n: Fever: n = 4, Fatigue: n = 25, Muscosites: n = 5, Diarrhea: n = 2, Constipation: n = 14, Neutropenia: n = 6, Thrombcytopenia: n = 14 Side effects - Placebo in n: Fever: n = 3, Fatigue: n = 21, Mucositis: n = 4, Constipation: n = 12, Neutropenia: n = 4, Thrombcytopenia: n = 12, Febrile neutropenia: n = 1no significant differencestropenia: n = 1 no significant differences)
Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis + (Number in % with grade 3-4 After 4th cycle intervention arm (paste): 26.3, intervention arm (tablets): 43.7, placebo arm: 42.8; p = 0.01)
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (Number of CR/PR/PD/SD/NA: no significant difference between arms (lycopene: 10/10/3/1/1, placebo: 5/6/8/1/5; p = 0.100, not significant))
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (Number of patients ITT: not reported PP: intervention arm: A: grade 0: 13/16; grade 1: 2/16, grade 2: 1/16; control arm: grade 0: 6/16; grade 1: 5/16, grade 2: 4/16; grade 4: 1/16)
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Number of patients: ITT: not reported PP: intervention arm: grade 0: 13/14; grade 1: 1/14; control arm: grade 0: 8/16; grade 1: 5/16, grade 2: 2/16; grade 4: 1/16)
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Number with CIPN ITT: intervention arm: 5/ … Number with CIPNITT: intervention arm: 5/16 (31.25%); control arm: 13/19 (68.4%); p = 0.03PP: intervention arm: 3/14 (21.4%, mild: n = 1, moderate: n = 2); control arm: 11/16 (68.5%, mild: n = 4, moderate: n = 4, severe: n = 3); p = 0.026; RR = 2.51 (95% CI: 1.16,5.47)CIPN score. Mean (SD): ITT: not reported PP: intervention arm: 4.99 (1.33); control arm: 10.47 (10.62); p = 0.023Neurolog. Data (number of patients)intervention arm: mainly numbness/paresthesia limited to fingers/toes ( n = 1), stocking-and-glove distribution (n = 2), ankle hyporelexia (n = 2)control arm: mainly numbness/paresthesia limited to fingers/toes (n = 4), or extended to knees/elbows (n = 3), stocking-and-glove distribution ( n = 4)Neurophysiolog. DataIn each case sign. difference in amplitude sensor. Action potential: N. ulnaris (p = 0.021), peroneus superficialis (p = 0.017); suralis (p = 0.046)Otherwise no sign. Differences(p = 0.046) Otherwise no sign. Differences)
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (Number with PIPN ITT: intervention arm: 5/ … Number with PIPNITT: intervention arm: 5/18 (27.8%); control arm: 13/19 (68.4%); p = 0.032PP: intervention arm: 3/16 (18.7%); 10/16 (62.5%); p = 0.03; RR = 0.3 (95% CI: 0.1, 0.9)PIPN score. Mean (SD): ITT: not reported PP: intervention arm: 2.25 (5.1) (range: 0-15), control arm: 11 (11.63; range: 0-32); p = 0.01Neurolog. Data (number of patients)intervention arm: mainly numbness/paresthesia limited to fingers/toes (n = 1), stocking-and-glove distribution (n = 2), ankle hyporeflexia ( n = 2)control arm: mainly numbness/paresthesia limited to fingers/toes (n = 3), or extended to knees/elbows ( n = 3), stocking-and-glove distribution (n = 4)Neurophysiolog. DataIn each case sign. Difference in amplitude sensor. Action potential: N. ulnaris (p = 0.014), peroneus superfic. (p = 0.003); sural nerve (p = 0.008)Otherwise no sign. differences(p = 0.008) Otherwise no sign. differences)
Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients + (One death occurred 62 days post-operation … One death occurred 62 days post-operation in the control arm (segmentectomy) due to bleeding from esophageal varices 2 weeks after surgery, followed by multi-organ failure. No other surgical mortalities or readmissions related to the surgery were reported.ions related to the surgery were reported.)
Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (One month after completion of radiotherapy: taste perception threshold was increased in the placebo arm for al four tastes (p = 0.001), in the intervention arm, there was only slight increase in threshold for perception of the salty taste (p = 0.046))
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (Only one patient from the intervention arm did not reach CR and died)
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (Over both cycles: 1. nausea score after 24 … Over both cycles:1. nausea score after 24 hours2. nausea score 3 hours after first doseSign. Treatment effect in favor of ginger after 3 or 24 hours: Within-group comparison between cycles 1-2: Arm 1 Verum-placeboMD - 0.93±3.39Arm 2Placebo - verumMD 1.80±2.33 Then t-test inter-group comparison with above values: Ta = -2.571, df = 28, p = 0.01Comparison of the cross-over regimes and the comparison between the two cycles showed no differences, i.e. ginger was superior to placebo in both cycles, irrespective of cycle and armboth cycles, irrespective of cycle and arm)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Over the course of the intervention and after: no difference (p=0.3295) between arms)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Over the course of the intervention and after: no differences for pain (p=0.6048), analgesic use (p=0.6671), no delay in time to 20% pain increase (p=0.4614) between arms)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Over the course of the intervention and after: no difference for nausea (p=0.7105) or antiemetic consumption (p=0.6124) between arms)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Over the course of the intervention and after: no difference for weight fluctuations (p=0.1454) or need for a feeding tube (no p-value) between arms.)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Over the course of the intervention and after: no differences for mood (p=0.3214) and sleep quality (p=0.4438) between arms)
Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (Overall incidence of grade 2 diarrhea: intervention arm 20.5% vs. control arm 44.5% (p = 0.04))