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- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (The toxicities did not differ significantl … The toxicities did not differ significantly by Poly E dose level or compared with placebo</br>All DLTs (dose-limiting toxicity) occurred in participants receiving active Poly E. The frequency of DLTs was 6.25% (1 of 16) for dose level 1, 27% (3 of 11) for dose level 2, and 33% (1 of 3) for dose level 3.evel 2, and 33% (1 of 3) for dose level 3.)