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- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (There were signifcantly (p<0.001) fewer … There were signifcantly (p<0.001) fewer urogenial symptoms (evaluted as maximum extent) in the enzyme-arm: enzyme-arm = 0.93 (0.52); placebo-arm = 1.38 (0.56). The treatment effect was observed from 1 week after start of radiation therapy until the last follow-up visit 5 month after intervention.t follow-up visit 5 month after intervention.)