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- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (During the course of radiation therapy in … During the course of radiation therapy in both arms most of the patients showed a slight increase in frequency of micturition and dysuria. 10% of the enzyme arm and 38.3% of the control arm showed increased severity and frequency of micturition with dysuria, pelvic pain and frequent frank haematuria.pelvic pain and frequent frank haematuria.)