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List of results

Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (No significant difference after 5 weeks * … No significant difference after 5 weeks* Sativex arm = 7.2% vs. placebo arm = 9.5% (median difference = −1.84%; CI: −6.19%, 1.50%; p=0.274, not significant)Subgroup analysis with US population * shows effects for Sativex arm (p=0.03), especially for patients under 65 years of ageecially for patients under 65 years of age)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (No significant difference between arms. A … No significant difference between arms. At cycle 1: worsening of the BFI score was smaller with ginger than placebo (treatment difference -0.23, 95% CI: -0.97 to 0.51). At cycle 2: the situation was different: worsening with ginger was slightly higher than with placebo (treatment difference 0.09, 95% CI –0.71 to 0.89). During both cycles, differences in BFI scores were negligible.differences in BFI scores were negligible.)
Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (No significant difference between patients who did develop aromatase inhibitor-induced arthralgia and those patients who did not develop aromatase inhibitor-induced arthralgia)
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (No significant difference between the arms at each assessed time point (p = 0.15-0.94); this was also the case with the duration of the reaction.)
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (No significant difference for the 7 weeks of intervention)
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (No significant difference ginger vs. placebo: 10.6% vs. 8.5% (p=0.78) on day 1 of chemotherapy No significant group differences (p>0.05) on day 2-5 of chemotherapy)
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (No significant difference in all cycles (p>0.05))
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significant difference in median improv … No significant difference in median improvement for ITT after 5 weeks:* Intervention 10.7% vs. placebo 4.5%; treatment difference = 3.41%, 95% CI: 0.00% - 8.16%; p=0.0854; Significant difference for per protocol analysis after 5 weeks: * Intervention 15.5% vs. placebo 6.3%; treatment difference = 5.49%, 95% CI: 0.00% - 11.11%; p=0.0378 = 5.49%, 95% CI: 0.00% - 11.11%; p=0.0378)
Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer + (No significant difference in the rate of seroconversion against vaccine antigens according to selected antigens (PS1, PS5, PS6, PS9, PS14, PS18))
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (No significant differences)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (No significant differences)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No significant differences)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (No significant differences (nausea, vomiting, depression, shortness of breath, memory, appetite, diarrhea, urination, skin, sleep, fatigue, activity, mood, work, relationships, walking, quality of life))
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (No significant differences before therapy, in the last week: significant difference of serum zinc levels between the two arm: intervention arm: 20.5 (39.9) vs. placebo arm: -1.5 (39.1), p = 0.02)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (No significant differences between THC:CBD arm/THC arm and placebo arm)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (No significant differences between THC:CBD arm/THC arm and placebo arm.)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (No significant differences between all three arms at T1 (18 weeks post surgery) and T2 (24 weeks post surgery))
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (No significant differences between all thr … No significant differences between all three arms at T1 (18 weeks post surgery). Significant better values for intervention 1 than Intervention 2 in the total scale as well as in the subscale “functional well-beeing” at T2 (24 weeks post surgery) (total scale: intervention 1: 118.60 [114.93,112.26], intervention 3: 111.70 [108.10,115.30]; p=0.03, “functional wellbeing”: intervention 1: 23.17 [22.01,24.33], intervention 3: 21.04 [19.90,22.17]; p=0.03). No significant differences between the other arms.ficant differences between the other arms.)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (No significant differences between all three arms at T1 (18 weeks post surgery) and T2 (24 weeks post surgery).)
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significant differences between arms after 3 weeks and 5 weeks (p=0.6410; p=0.4217).)

Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (No significant differences between arms at any time point)

Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (No significant differences between arms.)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (No significant differences between interve … No significant differences between intervention group and control group Number (%):Hematologic side effects:Leukopenia: intervention: 10 (33.3), control: 10 (33.3), not significant Thrombocytopenia: intervention: 4 (13.3), control: 4 (13.3), not significant Hyperbilirubinemia: intervention: 4 (13.3), control: 2 (6.7), not significant AST/ALT elevation: intervention: 4 (13.3), control: 6 (20), not significant Grade 3 onlyHematologic side effects:Intervention: n = 1 (thrombocytopenia), control: n = 1 (leukopenia)Non-hematologic side effects: Nausea: intervention: 10 (33.3), control: 5 (13.3%), not significant Stomatitis: intervention: 4 (13.3), control: 4 (13.3), not significant Diarrhea: intervention: 2 (6.7), control: 2 (6.7), not significant Peripheral neuropathy: intervention: 1 (3.3%), control: 1 (3.3%), not significant(3.3%), control: 1 (3.3%), not significant)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (No significant differences between the arms, majority of patients did not report episodes of vomiting (mean incidence = 0.5))
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (No significant differences between the arms)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (No significant differences between the arms.)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (No significant differences between the groups over the 4 cycles)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (No significant differences between the groups over the 4 cycles)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (No significant differences between the treatment arms (from day 0 until day 21); no p-value reported)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (No significant differences in VAS scores; No significant differences in doses of analgesic medication consumption)
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (No significant differences in body weight, BMI, fat (%) between intervention arm compared to comparison arm (p>0.05, p>0.05, p>0.05) after 9 weeks)
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (No significant differences in frequencies … No significant differences in frequencies between arms for common adverse events, e.g. nausea/vomiting, fatigue, pain, anemia, dizziness, dyspnea, diarrhea, obstipation, vertigo (all p's ≥ .42) No differences for CannTox scales dizziness, feeling good, feeling high, hallucinations, palpitations, panic attacks, feeling active or unsteady walkingSee Arms/Side effects for detailed descriptionArms/Side effects for detailed description)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No significant differences in median durat … No significant differences in median duration of PSA progression-free survival;median duration of tumor progression-free survival and median duration of clinical progression-free survival could not be reliably assessed due to the lack of regularly scheduled tumor imaging lack of regularly scheduled tumor imaging)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (No significant differences in the change from baseline to 6 months)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (No significant differences in the interval … No significant differences in the interval to taste alterations;the only factor that had a significant affect in influencing the outcome was the amount of oral mucosa in the radiation field (p = 0.004)+ Zinc sulfate did not favorably affect most other clinical parameters eitherfect most other clinical parameters either)
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (No significant differences p>0.05 on day 1-5 of chemotherapy)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (No significant differences regarding general health status and the 5 dimensions of the questionnaire used (mobility, self-care, usual activities, pain, anxiety/depression (numbers not given, only graphs))
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (No significant group differences between i … No significant group differences between intervention groups combined and placebo: OR (95% CI)* Nabiximol (1-4 sprays) + nabiximol (6-10 sprays) + nabiximol (11-16 sprays) vs. placebo =1.54 (0.95, 2.50), p = 0.077* Significant difference for nabiximol (1-4 sprays) vs. placebo = 1.87, p=0.038Otherwise no differences:* Nabiximol (6-10 sprays)/nabiximol (11-16 sprays) vs. placebo: not significant11-16 sprays) vs. placebo: not significant)
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (No significant group differences for incid … No significant group differences for incidence of nausea: ginger vs. placebo: 69.0% vs. 56.5% (p=0.174), incidence of vomiting: ginger vs. placebo: 8.5% vs. 15.9% (p=0.309), in the mean nausea scores (p=0.246) and the frequency of vomiting (p=0.256); no differences even after controlling for the intake of aprepitant 2 days after chemotherapyke of aprepitant 2 days after chemotherapy)
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (No statistical differences in baseline zinc serum levels; at the end of the supplementation period, although zinc serum levels were higher in the zinc group, the difference between the groups was not significant)
Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (No statistical relationship between the administration of zinc and esophagitis (p = 0.596); incidence of esophagitis was lower in the patients with normal serum zinc levels before and after RT, but that was not statistically signifiicant (p = 0.351))
Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (No statistical tests because of low numbers of patients (control arm: 96.5% vs. intervention arm: 98.1%))
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (No statistically difference between the two patient arms pre-treatment and post-treatment)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (No statistically significant difference in weight loss between the two arms at the end of radiotherapy)
Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders + (No statistically significant difference in loss of smell, distortion of smell, loss of taste, or distortion of taste; Taste and smell changes were highly correlated (p < .0001))
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (No statistically significant difference in mortality between the two groups during the 46-months follow up; median progression-free survival for both arms: 10.5 months)