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- Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (No significant differences in the interval … No significant differences in the interval to taste alterations;</br>the only factor that had a significant affect in influencing the outcome was the amount of oral mucosa in the radiation field (p = 0.004)</br>+ Zinc sulfate did not favorably affect most other clinical parameters eitherfect most other clinical parameters either)