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List of results

Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (No significant differences between the arms.)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (No significant differences between the groups over the 4 cycles)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (No significant differences between the groups over the 4 cycles)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (No significant differences between the treatment arms (from day 0 until day 21); no p-value reported)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (No significant differences in VAS scores; No significant differences in doses of analgesic medication consumption)
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (No significant differences in body weight, BMI, fat (%) between intervention arm compared to comparison arm (p>0.05, p>0.05, p>0.05) after 9 weeks)
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (No significant differences in frequencies … No significant differences in frequencies between arms for common adverse events, e.g. nausea/vomiting, fatigue, pain, anemia, dizziness, dyspnea, diarrhea, obstipation, vertigo (all p's ≥ .42) No differences for CannTox scales dizziness, feeling good, feeling high, hallucinations, palpitations, panic attacks, feeling active or unsteady walkingSee Arms/Side effects for detailed descriptionArms/Side effects for detailed description)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No significant differences in median durat … No significant differences in median duration of PSA progression-free survival;median duration of tumor progression-free survival and median duration of clinical progression-free survival could not be reliably assessed due to the lack of regularly scheduled tumor imaging lack of regularly scheduled tumor imaging)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (No significant differences in the change from baseline to 6 months)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (No significant differences in the interval … No significant differences in the interval to taste alterations;the only factor that had a significant affect in influencing the outcome was the amount of oral mucosa in the radiation field (p = 0.004)+ Zinc sulfate did not favorably affect most other clinical parameters eitherfect most other clinical parameters either)
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (No significant differences p>0.05 on day 1-5 of chemotherapy)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (No significant differences regarding general health status and the 5 dimensions of the questionnaire used (mobility, self-care, usual activities, pain, anxiety/depression (numbers not given, only graphs))
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (No significant group differences between i … No significant group differences between intervention groups combined and placebo: OR (95% CI)* Nabiximol (1-4 sprays) + nabiximol (6-10 sprays) + nabiximol (11-16 sprays) vs. placebo =1.54 (0.95, 2.50), p = 0.077* Significant difference for nabiximol (1-4 sprays) vs. placebo = 1.87, p=0.038Otherwise no differences:* Nabiximol (6-10 sprays)/nabiximol (11-16 sprays) vs. placebo: not significant11-16 sprays) vs. placebo: not significant)
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (No significant group differences for incid … No significant group differences for incidence of nausea: ginger vs. placebo: 69.0% vs. 56.5% (p=0.174), incidence of vomiting: ginger vs. placebo: 8.5% vs. 15.9% (p=0.309), in the mean nausea scores (p=0.246) and the frequency of vomiting (p=0.256); no differences even after controlling for the intake of aprepitant 2 days after chemotherapyke of aprepitant 2 days after chemotherapy)
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (No statistical differences in baseline zinc serum levels; at the end of the supplementation period, although zinc serum levels were higher in the zinc group, the difference between the groups was not significant)
Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (No statistical relationship between the administration of zinc and esophagitis (p = 0.596); incidence of esophagitis was lower in the patients with normal serum zinc levels before and after RT, but that was not statistically signifiicant (p = 0.351))
Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (No statistical tests because of low numbers of patients (control arm: 96.5% vs. intervention arm: 98.1%))
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (No statistically difference between the two patient arms pre-treatment and post-treatment)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (No statistically significant difference in weight loss between the two arms at the end of radiotherapy)
Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders + (No statistically significant difference in loss of smell, distortion of smell, loss of taste, or distortion of taste; Taste and smell changes were highly correlated (p < .0001))
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (No statistically significant difference in mortality between the two groups during the 46-months follow up; median progression-free survival for both arms: 10.5 months)
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (No statistically significant difference was noted between the arms)
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (No statistically significant difference; w … No statistically significant difference;weight loss increased as the week of radiotherapy advanced (Friedman chi-square test 40.42 p < 0.001); statistically significant difference in body weight measured before radiotherapy and the first day after radiotherapyotherapy and the first day after radiotherapy)
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (No statistically significant difference; median overall survival in the intervention arm was 39 months and 40 months in control arm)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (No statistically significant differences)

Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (No statistically significant differences between the arms)

Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (No statistically significant differences i … No statistically significant differences in the change in BCPT-MS scores between arms;The subscales for pain, stiffness, and physical function on the AUSCAN, WOMAC, PROMIS and the HGST did not show any differences between arms for the change from baseline to 6 months;Exploratory analyses within each arm did not show clinically significant correlations between free or total serum 25(OH)D and BCPT-MS scores, hand-grip strength or estradiol concentrations-grip strength or estradiol concentrations)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (No values reported, only tables: no significant differences in incidence and duration)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (No values reported, only tables: no significant differences)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (No values reported, only tables: no significant differences)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (No values reported, only tables: no significant differences)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (No values reported, only tables: no significant differences)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (No values reported, only tables: no significant differences in duration)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (Not significant taste alterations during the first 2 months between the arms (p = 0.16))
Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (Number (%) of patients requiring therapy i … Number (%) of patients requiring therapy interruption:* Curcumin arm: 7 (17.95%), Povidone-iodine arm: 9 (24%) ns.Number of days lost: mean (SD)* Curcumin arm: 7 (0), Povidone-iodine arm: 7.25 (0.56) ns.Weight loss: mean (SD)* Curcumin arm: 3.92 (2.13), Povidone-iodine arm: 4.45 (2.15); p < 0.001ovidone-iodine arm: 4.45 (2.15); p < 0.001)
Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial + (Number (%) with acute complications Vitam … Number (%) with acute complicationsVitamin E vs. placebo arm overall: p = 0.216, not sign. None: vitamin E: 10 (35.7), placebo arm: 9 (34.6)mild nausea: vitamin E: 12 (42.8), placebo arm: 10 (38.5)vomiting: vitamin E: 4 (14.3), placebo arm: 5 (19.2)fever: vitamin E: 4 (14.3), placebo arm: 1 (3.8)candidiasis: vitamin E: 2 (7.1), placebo arm: 4 (15.4)bleeding: vitamin E: 2 (7.1), placebo arm: 9 (34.6) vitamin E: 2 (7.1), placebo arm: 9 (34.6))
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Number (%): Intervention arm: 33 (31.4; 95% CI: 22.6, 40.3), placebo arm: 39 (37.1; 95% CI: 27.9, 46.4); p = 0.38, not significant)
Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis + (Number in % with grade 3-4 After 1st cyc … Number in % with grade 3-4 After 1st cycleintervention arm (paste): 7.6, intervention arm (tablets): 8.3, placebo arm: 7.6; p = nsAfter 2nd cycleintervention arm (paste): 11.5, intervention arm (tablets): 12.5, placebo arm: 15.3; p = nsAfter 3rd cycleintervention arm (paste): 21.7, intervention arm (tablets): 33.3, placebo arm: 31.8; p = 0.01ablets): 33.3, placebo arm: 31.8; p = 0.01)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Number in %: * Intervention arm: 28.6%, Placebo arm: 87.5%; p = 0.002)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Number of patients with HFS ≥ grade 1 (%): Intervention group: 22 (76.7), control group: 25 (83.3), not significant)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Number of patients with HFS ≥ grade 2 (%): Intervention group: 18 (60), control group: 18 (60); no significant difference; p = 1 (Grade 2: intervention group: 13, control group: 12; Grade 3: intervention group: 5, control group: 6))
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Number of tablets Mean(SD Intervention vs. placebo: Ondansetron: p=0.99, Domperidone / metoclopramide: p=0.4 No significant difference)
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (On average (across all time points) there are no sig. differences between the two arms (βG=0.31 (0.98); p=0.753). But in both arms there is a decrease in symptoms, which is sig. stronger in intervention arm over time (βI= -1.12 (0.49); p=0.231).)
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (On average (across all time points) there are no sig. differences between the two arms (βG=-0.63 (1.23); p=0.61). However, there is a decrease in symptoms in both arms, which is sig. stronger in intervention arm over time (βI= -3.17 (1.41); p=0.02).)
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (On average (across all time points), there … On average (across all time points), there are sig. lower (better) values in intervention than in passive control arm (βG=-21.22 (4.93); p<0.001). In addition, there is a sig. different development in the two arms, in the sense that the values in intervention tend to remain the same, whereas they tend to increase in passive control arm (βI= -2.41 (1.38); p=0.0107).ive control arm (βI= -2.41 (1.38); p=0.0107).)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (On day 1 of chemotherapy, acute average na … On day 1 of chemotherapy, acute average nausea: * intervention arms vs. placebo (change, SE): -0.350, -0.140 (p=0.013)* sign. single difference placebo vs. intervention arm 0.5g, p=0.046, no sign. differences for other individual comparisons (1g vs. 0.5g, p=0.076; placebo vs. 1.5g, p=0.738)Maximum: * intervention arms vs. placebo (change, SE): -0.470, 0.160 (p=0.003)* sign. single difference placebo vs. 1.0g (p=0.036), placebo vs. 0.5g (p=0.017)* no sign. difference for placebo vs. 1.5g (p=0.431) difference for placebo vs. 1.5g (p=0.431))
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (On day 7, 50% of the patients reported having complete eradication of odour; 9 of the patients were from the metronidazole arm and 6 patients were from the green tea arm)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Only 9% of the total study population had … Only 9% of the total study population had sufficient levels (≥30 ng/mL) of 25-hydroxyvitamin D at baseline;Plasma 25-hydroxyvitamin D levels increased into the sufficient range at the time of the first restaging (T1) among patients in intervention arm (median level, 32.0 ng/mL (IQR, 25.7-39.5 ng/mL)), whereas patients in control arm had no substantial change in their 25-hydroxyvitamin D level (median level, 18.7 ng/mL (IQR, 16.1-22.5 ng/mL)) (difference, 12.8 ng/mL (95% CI, 9.0- 16.6 ng/mL); p<.001);T2 (second restaging): intervention arm: median 25-hydroxyvitamin D level of 35.2 ng/mL (IQR, 25.0-45.4 ng/mL) vs. control arm: 18.5 ng/mL (IQR, 16.0-22.6 ng/mL) (difference, 16.7 ng/mL (95% CI, 10.9-22.5 ng/mL); p<.001);At treatment discontinuation: intervention arm: maintained vitamin D sufficiency and median 25-hydroxyvitamin D level of 34.8 ng/mL (IQR, 24.9- 44.7 ng/mL) vs. control arm: still deficient in vitamin D (18.7 ng/mL (IQR, 13.9-23.0 ng/mL)) (difference, 16.2 ng/mL [95% CI, 9.9-22.4 ng/mL]; p<.001)ce, 16.2 ng/mL [95% CI, 9.9-22.4 ng/mL]; p<.001))
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Only the breast cancer patients were evaluated: no sig. difference between intervention and control.)
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Only the breast cancer patients were evaluated: no sig. difference between intervention and control.)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Onset of mucositis after transplantation comparable in both selenium and placebo arm; p=0.81)