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List of results

Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (T0: before receiving radiotherapy, 15 pati … T0: before receiving radiotherapy, 15 patients (88.9%) had already experienced a reduction in taste acuity in at least 1 of the detection or recognition thresholds for at least 1 of the 4 taste qualities, whereas 66.7% of the patients had 4 taste qualities compromised (in both detection and recognition thresholds),the moment of subjective worsening of taste acuity reported by the patient to be the moment to start zinc sulfate or placebo treatment: after 1 week of radiotherapy, 55% of the placebo arm versus 11% of the intervention had already begun their respective prescribed treatment,2nd week: taste alteration awareness rose to 77% for the placebo arm and 66% for the intervention arm,4th week: taste alteration awareness rose to 100% for both groups;During radiotherapy, the worsening of taste acuity in the placebo arm was greater than in the intervention armm was greater than in the intervention arm)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (The difference of pretreatment serum zinc levels between the arms was not statistically significant, significant differences posttreatment with higher levels in the intervention arm (mean (SD): 138.76 (32.71) vs. 114.06 (26.08), p = .023))
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (The incidence of any grade 3 or 4 adverse … The incidence of any grade 3 or 4 adverse events was not significantly different;serious adverse events, generally those requiring hospitalization, were observed in 41% of placebo-treated patients and 27% of DN-101-treated patients (p = .023);Among the grade 3 or 4 nonhematologic toxicities, the most common were fatigue (16% placebo; 8% DN-101), infection (13% placebo; 8% DN- 101), and hyperglycemia (12% placebo; 6% DN-101)and hyperglycemia (12% placebo; 6% DN-101))
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (The pain decreased in both arms from day 1 … The pain decreased in both arms from day 1 to day 7 after surgery.Day 1: Enzyme arm = 5.35(1.14); control arm = 6.06(1.23) p =0.013Day 3: Enzyme arm = 4.06(1.13); control arm = 4.73(1.25) p =0.019Day 7: Enzyme arm = 2.23(1.02) ; control arm = 2.76(1.17) p=0.0443(1.02) ; control arm = 2.76(1.17) p=0.044)
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (The percentages of complete responses and partial responses achieved in patients concomitantly treated with aloe were significantly higher than in those who received chemotherapy alone: Aloe arm = 40/119 (34%) vs. Control arm = 23/121 (19%), p<0.01.)
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (The response rate was not significantly different between the arms)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (The severity followed the same sequence tr … The severity followed the same sequence trajectory in all 3 arms with a peak effect commonly occurring within the first week after end of radiation, although for 10 patients, the peak reaction occurred at 2 weeks after radiation (7 in the aloe cream, 1 in the placebo cream, and 2 in the powder arm)Erythema as the maximum reaction (CSSP score 1-4) occurred in 16.5% of the powder, 8.6% of the aloe cream, and 6.6% of the placebo cream arms. Dry desquamation as a maximum reaction (CSSP score 5-6) occurred in 35.4% of the powder, 28.4% of the aloe cream, and 29% of the placebo cream arms. Moist desquamation in < 50% of the field as the maximum reaction (CSSP score 7-8) occurred in 44.3% of the powder, 49.4% of the aloe cream, and 56.6% of the placebo cream arms. Moist desquamation in > 50% of the field as a maximum reaction (CSSP score 9-10) occurred in 3.8% of the powder, 13.6% of the aloe cream, and 7.9% of the placebo cream arms. aloe cream, and 7.9% of the placebo cream arms.)
Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy + (There was no significant difference in vomiting (frequency of grade) between green tea arm and placebo arm during 2nd-5th week (p=0.4-0.7).)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Time in days: Intervention arm vs. placebo … Time in days:Intervention arm vs. placebo arm; p = 0.73, not siginificant (numbers not given, only Kaplan-Meier curve)Incidence after 60 days in % (95% CI): Intervention arm: 13.7 (6.7, 20.6), placebo arm: 15.4 (8.2, 22.7), not significantIncidence after 120 days: Intervention arm: 36.9 (25.7, 48.1), placebo arm: 41.0 (30.3, 51.8), not significantbo arm: 41.0 (30.3, 51.8), not significant)

Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial + (Time of onset of symptoms (graph only): p = 0.66)

Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (Type and frequency of side effect: Enzyme- … Type and frequency of side effect: Enzyme-arm; control-arm1. diarrhoea: 15; 7 2. diarrhoea + fever: 1; 1 3. constipation: 0; 1 4. febrile infection + burning on urination: 1; 0 5. diarrhoea + nausea: 2; 4 6. diarrhoea + nausea + vomiting + reduced general condition: 0; 1 7. erythema: 1; 0 8. pain in the groin + burning on urination: 1; 0 9. erythema + diarrhoea: 2; 010. nausea: 0; 1 11. urinary tract infection: 1; 1 12. diarrhoea + urinary tract infection; 1;0 13. diarrhoea + burning on urination: 1; 0 14. burning on urination: 2; 0ion: 1; 0 14. burning on urination: 2; 0)
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (Type and number of additional medications … Type and number of additional medications in Enzyme-arm; control-arm:Cardiovascular agents: 34; 32Antiemetics and gastrointestinal agents: 20; 30Psychotropic drugs and antidepressants: 9; 19Analgesics/spasmolytics: 5; 9Diuretics/aldosterone anatagonists: 1; 5Antibiotics/chemotherapy: 5; 4Hypnotics: 7; 3Other: 21; 23rapy: 5; 4 Hypnotics: 7; 3 Other: 21; 23)
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (Vitamin D treatment increased mean 25-OHD significantly, from 36 (±11) nmol/L to 81 (±26) nmol/L (p<0.001), while mean 25-OHD in the placebo arm remained stable)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Vomiting intervention vs. placebo: p=0.5 Vomiting grade 3 intervention vs. placebo: 3% vs. 3% No significant difference)
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Weight loss in the two groups was very similar)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Within 6 months of enrollment: no signific … Within 6 months of enrollment: no significant differences in PSA decline;at any time while on study: PSA decline achieved in 52% of placebo- treated patients and 63% of DN-101-treated patients (p = .07);median time to PSA response was 5.3 months in placebo-treated patients and 2.9 months in DN-101-treated patients (p = .06)onths in DN-101-treated patients (p = .06))
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Zinc not provide a benefit: patients in the intervention arm were unable to tolerate more courses of weekly chemotherapy than patients in the placebo arm)
Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer + (Zinc supplementation increased the zinc plasma concentrations)