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- Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Most common adverse events: neutropenia (2 … Most common adverse events: neutropenia (24 patients (35%)) and hypertension (9 patients (13%)), diarrhea (1 patient (1%)),</br>the only adverse events that were reported as possibly related to vitamin D3 were hyperphosphatemia (1 patient in intervention arm) and kidney stones (1 patient in the placebo arm)dney stones (1 patient in the placebo arm))