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- Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (No side effects associated with vitamin E reported No sign. differences in patients with severe side effects: intervention arm: grade 3 n = 2 (thrombocytopenia; hypersensitivity, both most likely associated with CTX), placebo arm: grade 4 CNS hemorrhage)