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List of results

Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (No side effects associated with placebo reported No sign. differences in patients with severe side effects: intervention arm: grade 3 n = 2 (thrombocytopenia; hypersensitivity, both most likely associated with CTX), placebo arm: grade 4 CNS hemorrhage)
Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (No side effects associated with vitamin E reported No sign. differences in patients with severe side effects: intervention arm: grade 3 n = 2 (thrombocytopenia; hypersensitivity, both most likely associated with CTX), placebo arm: grade 4 CNS hemorrhage)
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (No side effects have been reported.)
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (No side effects in either arm. No indications from the patient files that ginkgo influenced the anti-tumor effect of cisplatin.)
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (No side effects in either arm. No indications from the patient files that ginkgo influenced the anti-tumor effect of cisplatin.)
Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer + (No side effects reported)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (No side effects reported No significant difference between arms (p=NI))
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (No side effects reported.)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (No side effects reported. No significant difference between arms (p=NI))
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (No side effects reported. No significant difference between arms (p=NI))
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (No side effects were reported)
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (No side effects were reported)
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (No side effects/interactions with lycopene)
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (No significant adverse event related to in … No significant adverse event related to intervention observed, none of the patients withdrewn from the study due to toxicity/side ffects, no dose reduction required in either arm. 2 patients discontinued the study early due to discontinuation of Chemotherapy after cycle 2 or due to 2nd degree dyspepsiater cycle 2 or due to 2nd degree dyspepsia)
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (No significant adverse event related to 6- … No significant adverse event related to 6-gingerol observed, none of the patients withdrewn from the study due to toxicity/side ffects, no dose reduction required in either arm. 1 patient discontinued the study early due to 3rd degree vomiting requiring hospitalization- placebo-arm: n=2 patients due to discontinuation of Chemotherapy after cycle 2 or due to 2nd degree dyspepsiater cycle 2 or due to 2nd degree dyspepsia)
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (No significant adverse events or side effects related to study medication noticed/reported throughout the trial)
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (No significant adverse events or side effects related to study medication noticed/reported throughout the trial)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (No significant arm difference. With regard to intervention-related side effects, intervention reported significantly more side effects than placebo (intervention: 63 vs. placebo: 35). Intervention reported more gastrointestinal side effects than placebo.)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (No significant arm difference. With regard to intervention-related side effects, intervention reported significantly more side effects than placebo (A: 63; B: 35). Intervention reported more gastrointestinal side effects than placebo.)
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (No significant difference between the arms.)
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (No significant difference between the arms.)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (No significant difference in the incidence of adverse events between subjects receiving ginger and placebo. No study-treatment-related adverse events were observed.)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (No significant difference in the incidence of adverse events between subjects receiving ginger and placebo. No study-treatment-related adverse events were observed.)
Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy + (No systematic indication, only one comment in discussion: "No change in liver enzyme testing has occurred in any patients receiving retinol palmitate")
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (No toxicities or significant adverse events.)
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (No.)

Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders + (Not arm specified: diarrhea, abdominal pain, cramps, diaphoresis)
Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders + (Not arm specified: diarrhea, abdominal pain, cramps, diaphoresis)

Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors + (Not arm specified: intolerance or dislike of tea product (n=4))
Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors + (Not arm specified: intolerance or dislike of tea product (n=4))
Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Not reported, although no allergic skin reactions to aloe have been documented.)
Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (Not separated between arms Only general indication of good tolerability)
Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (Not separated between arms: Unclear cause … Not separated between arms: Unclear cause: n=13 cystectomy (intervention arm: n=6, placebo arm: n=7), n=23 deceased (intervention arm: n=13, placebo arm: n=10);Report of side effects: intervention arm: n=7 and placebo arm: n=10, all grade 1 except n=1, grade 2 pain in the intervention arm; side effects were change in nails, back and neck pain, constipation, sleep disturbances, dizziness, and arthralgia, with one n=1 patient reporting nausea, pain, and stomach problems and another patient dizziness and diarrheaand another patient dizziness and diarrhea)
Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (Not separated between arms: Unclear cause … Not separated between arms: Unclear cause: n=13 cystectomy (intervention arm: n=6, placebo arm: n=7), n=23 deceased (intervention arm: n=13, placebo arm: n=10);Report of side effects: intervention arm: n=7 and placebo arm: n=10, all grade 1 except n=1, grade 2 pain in the intervention arm; side effects were change in nails, back and neck pain, constipation, sleep disturbances, dizziness, and arthralgia, with one n=1 patient reporting nausea, pain, and stomach problems and another patient dizziness and diarrheaand another patient dizziness and diarrhea)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (Not separated between arms: musculoskeletal (18%) and gastrointestinal (17%), no significant differences)
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (Not separated between arms: musculoskeletal (18%) and gastrointestinal (17%), no significant differences)
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (Not seperated by arm: Predominantly nausea, vomiting, diarrhea without differences between the arms (p=kA); according to the authors a consequence of chemotherapy)
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (Not seperated by arm: Predominantly nausea, vomiting, diarrhea without differences between the arms (p=kA); according to the authors a consequence of chemotherapy)
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (Number of side effects (ITT): Intervention arm: 16/18 (88.8%); control arm: 18/19 (94.7%); p = 0.96 (mainly nausea, vomiting and hair loss, no side effects associated with vitamin E, no deaths caused by vitamin E.)
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...) + (Occurrence of grade 3/4 nausea/vomiting, infections, diarrhea, constipation and nephrotoxicity)
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...) + (Occurrence of grade 3/4 nausea/vomiting, infections, diarrhea, constipation and nephrotoxicity)
Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (One case of lethargy in the placebo group, which was ongoing at follow-up. One case with diarrhoea.)
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (One case of vomiting probably related to the fish oil supplement)
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (One patient in the placebo arm discontinued the test solution due to unfavorable taste and was reported as a non-compliance.)
Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (Only general indication of good tolerability Not separated between arms)
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Overall 64% at least one event; assessed a … Overall 64% at least one event; assessed as probably intervention-associated with frequency ≥ 5%: Total n=41 (20.7%), of which somnolence n=6 (3%), dizziness n=6 (3%), nausea n=8 (4%)2 severe side effects associated with intervention: 1x constipation (with 360mg/day morphine equivalents), 1x moderate disorientation and somnolence on day 4 (with 2.5 daily sprays of Sativex)None of the deaths related to interventionNone of the deaths related to intervention)
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Overall 68% at least one event; assessed a … Overall 68% at least one event; assessed as probably intervention-associated with frequency ≥ 5%: Total n=64 (32.2%), of which somnolence n=18 (9%), dizziness n=15 (7.5%), nausea n=10 (5%)2 severe side effects associated with intervention: 1x constipation (with 360mg/day morphine equivalents), 1x moderate disorientation and somnolence on day 4 (with 2.5 daily sprays of Sativex)None of the deaths related to interventionNone of the deaths related to intervention)
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Overall adverse events 93.3%, severe adver … Overall adverse events 93.3%, severe adverse events: 33%;highest incidence of adverse events occurred in the gastrointestinal system: 72%, of which nausea, diarrhea, constipation, vomiting, and stomatitis were most frequent,most common severe adverse events: febrile neutropenia 4.6%, pneumonia 2.9%, dehydration 2.7%, disease progression 1.3%, dyspnea 1.1%, deep vein thrombosis 2.5%, 0.6% hypercalcemia, 0.2% hypercalcemia grade ≥ 3ypercalcemia, 0.2% hypercalcemia grade ≥ 3)
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Overall adverse events 93.5%, severe adver … Overall adverse events 93.5%, severe adverse events: 35%;highest incidence of adverse events occurred in the gastrointestinal system: 79%, of which nausea, diarrhea, constipation, vomiting, and stomatitis were most frequent,most common severe adverse events: febrile neutropenia 1.0%, pneumonia 3.1%, dehydration 2.5%, disease progression 2.5%, dyspnea 2.1%, deep vein thrombosis 0.6%, 5.9% hypercalcemia, 0.8% hypercalcemia grade ≥ 3ypercalcemia, 0.8% hypercalcemia grade ≥ 3)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (Overall associated with ginger: gastrointestinal symptoms, such as stage 2 heartburn, bruising/redness and skin rash)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (Overall associated with ginger: gastrointestinal symptoms, such as stage 2 heartburn, bruising/redness and skin rash)
Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Pain, fever, weakness, vomiting, itching, swelling, haemoptysis; no difference between the arms (p=kA) Radiation therapy gaps: 9 patients from the Enzyme-arm because of social/technical problems)