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List of results

Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (All analyses adhered to the modified intention-to-treat principle.)

Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (All nine subjects were analysed. This is a … All nine subjects were analysed. This is a Phase I study about safety, pharmapharmacokinetics, pharmacodynamics and not an efficacy study.PK: Statistical analyses for pharmacokinetic data included linear regression with 1/concentration weighting and descriptive statistics.PD: Means were compared via one way, one sided ANOVA followed by Tukey’s post hoc test.d ANOVA followed by Tukey’s post hoc test.)
Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (All participants analysed; no drop-outs)
Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (All patients were analysed in the intentio … All patients were analysed in the intention-to-treat evaluation, 71 patients in the per-protocol I evaluation and 83 patients in the per-protocol II evaluationPer-protocol I: Patients who discontinued before Visit 4 were excluded if the discontinuation was not efficacy-relatedPer-protocol II: Patients who discontinued before Visit 3 were excluded discontinued before Visit 3 were excluded)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (All patients who underwent randomization w … All patients who underwent randomization were included in the analysis;Relapse- and death-related outcomes were assessed according to randomization arm whether or not supplements were taken, whereas adverse events were assessed only in patients who continued to take the supplements (per protocol)ued to take the supplements (per protocol))
Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (All randomized patients were analyzed for efficacy, and 182 patients (93%) were evaluable for toxicity.)
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (All statistical analyses were performed us … All statistical analyses were performed using STATA version 15.1. P values less than 0.05 were considered significant. Demographic data of all participants were analyzed by using mean, 95%CI, and percentage.Nausea score from day 1 to day 5 was showed in mean, and analysis of variance (ANOVA) for a 2 × 2 crossover study was analyzed comparing treatment, sequence, and period effect.Nausea grading for each day was compared using proportion f grading between treatment after adjusted sequence and period by using random-effects ordered logistic regression.Vomiting and side effects were analyzed by comparing percentages between groups using random-effects logistic regression. using random-effects logistic regression.)
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (All statistical tests were two sided.)
Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (Analysis of covariance (ANCOVA) was used t … Analysis of covariance (ANCOVA) was used to assess between-group differences. Baseline values, chemotherapy status, and/or change in fat mass were used as covariates where appropriate. To assess differences in perceived energy between diet groups, sub-group analyses were conducted on the basis of chemotherapy status due to the prevalence of chemotherapy-related fatigue. Paired t-tests were used to assess within-group differences. Pearson correlation analyses were used to estimate associations between questionnaire results and serum β-hydroxybutyrate concentration, a biomarker of circulating ketones.The statistical analysis plan included an investigation for outliers, and the final analyses excluded them in order to lessen the influence of extreme observations on the overall results. One outlier (>3 standard deviations above the mean) was excluded from food craving analyses involving starches and high-fat foods. In addition, two participants in the KD group only partially completed the SF-12 at the follow-up visit; two participants in the KD group also did not complete all items on the VAS. Accordingly, these participants’ responses have been excluded from the corresponding analyses.een excluded from the corresponding analyses.)
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety. + (Arms were compared with t tests and chi-square tests)
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Baseline characteristics were compared amo … Baseline characteristics were compared among the three study arms using analysis of variance methods (ANOVA) for continuous variables and chi-square tests for categorical variables. To test the two primary hypotheses to detect a decrease in the mean changes in IGF-1 (or COX-2) gene expression between the lycopene (or fish oil) and placeboarms a t statistic was used with significance set at a probability <0.025 to adjust for the two comparisons. The same method was used to test for a decrease in IGF-1R with thelycopene supplement without any adjustment for multiple testing. Fisher’s exact test to determine whether a greater proportion of patients on the supplement arm achieved at least a 2-fold decrease in IGF-1 (or COX-2) expression when compared with the placebo group was used.An exploratory analyses was conducted using 2-way ANOVA methods to investigate the change in gene expression (pre to post-intervention) in DCT on the log2 scale due to the study arm (supplement or placebo), baseline tomato/fish intake (high or low) or their interaction. If statistical significance was observed, the Newman-Keuls post hoc test was used to identify which subsets were significantly different. Mean baseline and change from baseline results were presented on the log2 scale.ine results were presented on the log2 scale.)
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Baseline characteristics, QoL, and severit … Baseline characteristics, QoL, and severity of acute and delayed nausea and vomiting were compared between the 2 groups using independent samples t/nonparametric tests for continuous variables and Pearson’s χ2/Fisher’s exact tests for categorical variables.Incidence of acute and delayed nausea and vomiting was calculated as a binary variable (“yes” if participants had nausea or vomiting or “no” if participants had no nausea or vomiting) and was compared with a Pearson χ2 test.Two-tailed tests with a significance level of .05 were used for all analyses.e level of .05 were used for all analyses.)
Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Between-arm (ginger vs control) comparisons were performed using independent-samples t test (for quantitative variables) or χ2 and Fisher’s exact test (for categorical variables))
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Chi square test)
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (Chi- square test, independent T-test and Mann-Whitney test)
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study + (Chi-square test)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (Chi-square test)
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (Chi-square tests; Kaplan-Meier analyses; Cox proportional hazard models)
Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer + (Chi-squared test, inferential statistics of the linear logarithm model with Poison and paired t-test function)
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (Comparisons of baseline clinical and demog … Comparisons of baseline clinical and demographic variables between green tea arm, black tea arm and water arm was conducted using the ANOVA or Kruskal–Wallis tests for continuous variables and Fisher’s exact test or chisquare tests for categorical variables.If a statistically significant overall group effect was found, follow-up analysis was performed using pairwise t-tests or the Mann Whitney U tests to investigate which pairs of groups were significantly different.rs of groups were significantly different.)
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Data analyses were performed in three pati … Data analyses were performed in three patient populations:Full analysis set (FAS) population: n=61; 8 drop-outs; FAS population represents theintent-to-treat population with data available for > 2 weeks of treatmentPer protocol (PP) population: n=55 (29 enzyme-arm, 26 placebo-arm); FAS population exclusive of patients with major protocol deviations (termination of radiotherapy before week 5 or significant treatment interruptions > 1 week)Dresden (DD) population: n=46 (23 enzyme-arm, 23 placebo-arm) from Dresden from the PP population were analyzed separately from the PP population were analyzed separately)
Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Data are expressed as the mean value (± st … Data are expressed as the mean value (± standard deviation). One-way analysis of variance test (one-way ANOVA) followed by LSD post hoc test was used to assess any significant difference between the three groups. Paired t-test was used to assess any significant difference within each group at baseline and after chemotherapy. All probability values presented were two-tailed and p ≤ 0.05 was considered statistically significant. was considered statistically significant.)
Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Data of 70 patients were availible.)
Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (Evaluated ITT n=292, PP n=259; Sensitivity analysis n=216)
Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Event-free survival, time to second primar … Event-free survival, time to second primary tumor, and survival curves were constructed by the Kaplan–Meier technique and were compared by the log-rank test. The interaction between the effects of N-acetylcysteine and those of retinyl palmitate was tested with a proportional hazards model. Also, analyses of four arms were performed.lso, analyses of four arms were performed.)