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- Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (External beam radiotherapy: LINAC or Cobal … External beam radiotherapy: LINAC or Cobalt-10, total mean radiation dose (SD): 62.3 (9.13), radiotherapy duration (wks) (SD): 7.38 (1.28);</br>daily fractions of 180– 200 cGy lasting from 5 to 9 weeks, for a total dose of 45-70 Gy, the radiation fields were the same for all patients, and the tongue was always includedtients, and the tongue was always included)