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Property:Specifications on cancer therapies

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A
Oxaliplatin-based chemotherapy + calcium and magnesium supplements before and after oxaliplatin infusions  +
Oral or injection chemotherapy was administered to the patients according to the stage, except in stage IA and tumor size less than 2 cm  +
Chemotherapy regimens (n intervention vs. placebo arm): - AC, i.e. doxorubicin60 mg/m2 +cyclophosphamid 600 mg/m<sup>2</sup> (41 vs. 44) - CAF, i.e. cyclophosphamide 500mg/m2 + doxorubicin 50mg/ m<sup>2</sup> + 5-Fluorouracil 500mg/m<sup>2</sup> (19 vs. 18) - TAC, i.e. docetaxel 75mg/m<sup>2</sup> + doxorubicin 50mg/m<sup>2</sup> + cyclophosphamide 500mg/m<sup>2</sup> (15 vs. 13)  +
Chemotherapy treatment by a regimen including cyclophosphamide, doxorubicin, dacarbazine, gemcitabine, methotrexate, and 5-fluorouracil  +
Chemotherapy with adjuvant anthracycline (chemotherapy protocols: anthracycline, cyclophosphamide, doxorubicin, and 5-fluorouracil), no significant differences between arms in chemotherapy characteristics (p > 0.05)  +
Combination chemotherapy composed of cyclophosphamide doxorubicin, oncovine, and prednisone (CHOP), treatment consisted of sisted of 750 mg/m2 on first day of the treatment cycle intravenously (IV) cyclophosphamide, 50 mg/m2 IV doxorubicin, 1.4 mg/m2 IV vincristine, and 100 mg po days 1 to 5 prednisone; chemotherapy cycles were repeated every 28 days  +
Docetaxel was supplied commercially. Patients received, on a 28-day cycle, 35 mg/m<sup>2</sup> docetaxel i.v. on days 1, 8, and 15 over 1 hour  +
B
All patients chemotherapy (Intervention/ placebo arm): Doxorubicin/cyclophosphamide 35 (33 %)/ 37 (36 %) Doxorubicin/cyclophosphamide/taxane 56 (52 %)/ 54 (52 %) Other anthracycline-based chemo 6 (6 %)/ 0 (0 %) Other nonanthracycline-based chemo 10 (9 %)/ 12 (12 %) Adjuvant Tamoxifen therapy planned (intervention/ placebo arm): Yes 55 (51 %)/ 56 (54 %) No 52 (49 %)/ 47 (46 %)  +
Weekly docetaxel 36 mg/m<sup>2</sup> intravenously and dexamethasone (4 mg orally 12 hours before, 1 hour before, and 12 hours after docetaxel administration)  +
Chemotherapy with capecitabine Capecitabine alone (n = 43) Capecitabine + oxaliplatin (n = 24) Capecitabine + lapatinib (n = 5) Capecitabine + trastuzumab (n = 3) Capecitabine + cetuximab (n = 2)  +