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- Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial + (Oxiplatin-based chemotherapy (oxaliplatin … Oxiplatin-based chemotherapy (oxaliplatin + 5‑fluorouracil + leucovorin (FOLFOX4); oxaliplatin: 85 mg/m 2 intravenous (IV) on day 1, 5‑fluorouracil: 400 mg/m 2 IV bolus, followed by 600 mg/m 2 IV continuous infusion for 22 h on days 1 and 2, leucovorin: 200 mg/m 2 IV on days 1 and 2 as a 2‑h infusion before 5‑fluorouracil)2 as a 2‑h infusion before 5‑fluorouracil))