Semantic search
| Topic | Results during intervention | Results after intervention | Overall RoB judgment | |
|---|---|---|---|---|
| Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial | Median in weeks: vitamin E: 1 (Range: 0-5) vs. placebo arm: 2 (range: 0-5); p = 0.102, sign. | NA | ? | |
| Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial | Assesment weekly: Number of mucositis events: vitamin E arm significantly fewer than placebo arm (36 (21.6%) vs. 54 (33.5%); RR = 0.643; 95% KI: 0.42,0.98; p = 0.038, sign. Number of patients with pain/difficulty eating grade 2-3: vitamin E 3 (10.7%) vs. placebo arm 14 (53.8%); p = 0.0001, sign. | NA | ? | |
| Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation | NA | No sign. differences according to grade (no values given, only graph and p-values): grade 1: p = 0.31, grade 2: p = 0.25, grade: 3: p = 0.93, grade 4: p = 0.32 Mean length: no significant difference seperated by diagnosis (ALL, CML, AML). | ? | |
| Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer | Grade 0, 1, 2, and 3 mucositis were observed in 37.5%, 32.5%, 27.5%, and 2.5% of the patients; Grade 4 mucositis was not noted in any of the patients; there was no relationship between zinc replacement and mucositis (p = 0.159); incidence of mucositis was lower in the patients with normal serum zinc levels before and after RT, though that was not statistically signifiicant (p = 0.476) | NI | ? | |
| Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers | NI | The maximum extent of acute radiation side effects such as mucositis was significantly lower in the enzyme-arm than in the control-arm (p<0.0001): Enzyme-arm = 1.32(0.64); control-arm =2.24 (0.60). Mucosal reactions were graded about one grade lower and the number of patients with severe mucositis was considerably less: Numbers of patients per grade: Enzyme-arm: Grade 0 = 2; Grade 1 = 35; Grade 2 = 13; Grade 3 = 3 Control-arm: Grade 0 = 0; Grade 1 = 4; Grade 2 = 27; Grade 3 = 15 | ? |