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- Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (PRO: * Large sample according to power analysis * Double blinding CONTRA: * Dropout: 21/125 (17%): 5 vitamin E/placebo not taken and 16 dropouts (vitamin E: 9, placebo: 7) * No information on compliance * Poor report quality (e.g. some results missing))