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- Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial + (PRO: * Conducting a secondary analysis wi … PRO: </br>* Conducting a secondary analysis with more patients included; no differences in outcome </br>CONTRA: </br>* No blinding (placebo intervention was too expensive) </br>* Sample too small according to power analysis (< 150) </br>* Very high dropout rate intervention > control (23% > 15%), partly because inclusion criteria were tightened), partly because inclusion criteria were tightened)