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- Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (PRO: - CONTRA: * Results almost unusable, … PRO: -</br>CONTRA:</br>* Results almost unusable, no baseline values, graphs barely legible, many different cancer entities despite small sample, monocentric? etc.</br>* Only 16 patients in the evaluation of treatment success (even if this was unavoidable due to deaths)</br>* No statistical group comparisons carried out</br>* No information on the ethics voteed out * No information on the ethics vote)