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Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (18-49 years: 34.4%; ≥50 years: 65.6%)

Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (40.8% < 60 years (Intervention: 50% and placebo: 31.7%))
Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (67.6 (5.4))
Kadhim et al. (2021): Effect of Ginger Tea on Chemotherapy-Induced Nausea and Vomiting among Patients Attending the Oncology Teaching Hospital, Baghdad 2020 + (?)
Williams et al. (1996): Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity + (?)
Montazeri et al. (2013): Iranian Red Crescent Medical JournalEﬀect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients. + (?)
Sharp et al. (2009): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (?)
Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors + (Age (SD) per arm green tea arm: 56.6 (8.1) years placebo arm: 57.8 (8.5) years)
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine + (Age (mean ± SD): intervention arm 53.3 ± 9.9 years, placebo arm 51.9 ± 10.9 years)
Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients + (Age (mean ± SD): intervention arm 73 ± 9.8 years, control arm 73 ± 10.7 years)
Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Age (median): 66 years; range: intervention arm 24-94 years; placebo arm 38-86 years)
Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9 + (Age (years): <50 = 50%; ≥50 = 50%)
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (Age Mean (SD) = 57.0 (9.9) (ITT population))
Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Age Mean (SD): 56.7 (13.7))
Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Age Mean ± SD: carnitine arm 45.64 ± 9.941, silymarin arm 44.68 ± 12.44, control arm 44.455 ± 9.47;range 20–60 years)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Age at diagnosis (years) in median (IQR) - intervention group: 73 (68, 76) - placebo group: 73 (69, 76) Age at treatment (years) in median (IQR) - intervention group: 73 (68, 76) - placebo group: 73 (69, 76))
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...) + (Age at diagnosis (years) per arm, median (IQR): - intervention: 61 (12) - control: 60 (14))
Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (Age groups per arm (n) Enzyme-arm: 41-50 = 1; 51-60 = 2; 61-70 = 10; 71-80 = 12 Control-arm: 41-50 = 0; 51-60 = 3; 61-70 = 11; 71-80 = 12)
Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (Age in years (n = 45), mean (range): 60.2 (31-79))
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (Age in years, mean (SD) per arm: intervention arm: 44.8 (8.4) comparison arm 45.2 (15.0))
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Age in years, mean (SD) per group: ginger-group: 57.52 (7.24), placebo-group: 57.46 (7.82))
Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients + (Age in years, mean (SD), range: 57.5 (12.65), 18-82)
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (Age in years, mean (SD): 38.28 (14.07) Age in years, median (range): 38 (10-66))
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Age in years, mean (SD): 53.9 (13.8))
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Age in years, mean (SD): 61 (7.8))
Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer + (Age in years, mean (min-max) per arm: Selenium arm: 52.14 (22-81), placebo arm: 54.74 (18-81))
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (Age in years, mean (range): 63.49 (48-75))
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Age in years, mean: 64)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Age in years, median (range): 58 (26-82))
Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Age in years, median (range): 65 (31-85))
Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (Age in years, median (range): 72 (66-74))
Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Age in years: mean (SD) = 54.1 (10.41); range: 25-78)
Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Age range = 35-74 years, mean(SD) = 51.83(9.18) years)
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (Age: 50.3 ± 13.1)
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (Average age of arm intervention-placebo = 59 years Average age of arm placebo-intervention = 57 years)
Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (Intervention arm: 42-74 (median: 56) Control arm: 41-73 (median: 58))
Iovino et al. (2018): High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naive lymphocytes and prevents TTV reactivation + (Intervention arm: 63 (49-72) Control arm: 58 (47-65))
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Intervention arm: MW (SD): 50 (11) Placebo arm: MW (SD): 51 (11))
Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (Intervention arm: MW (SD): 51.5 (3.3), Range: 18-70 Placebo arm: MW (SD): 47.2 (3.5), Range: 18-79)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Intervention arm: mean (SD): 47.53 (13.49), range: 21-65 placebo arm: mean (SD): 46.93 (14.39), range: 18-68)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (Intervention arm: mean (SD): 48.2 (15.3) Control arm: mean (SD): 4.3 (15.2))
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Intervention arm: mean (SD): 49.5 (17.47), Range: 18–78 placebo arm: mean (SD): 52.82 (14.03), Range: 22 –71)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Intervention arm: mean (SD): 49.53 (13.75) Placebo arm: mean (SD): 50.88 (10.01))
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Intervention arm: mean (SD): 50 (11) Placebo arm: mean (SD): 51 (11))
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Intervention arm: mean (SD): 60 (8.8) Placebo arm: mean (SD): 63 (7.8))
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Intervention arm: mean (SD): 62 (13) Placebo arm: mean (SD): 60 (12))
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (Intervention arm: mean (SD): 62.5 (7.5) Placebo arm: mean (SD): 63.8 (13.3))
Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy + (Intervention arm: mean: 62 (43–78) Placebo arm: mean: 60 (29–77))
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Intervention arm: mean: 67.4 (53-78) Control arm: mean: 62.7 (35-86))

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