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List of results

• Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy  + (Mean age (SD) per arm: Green tea arm: 65.7 (9.3) years, placebo arm: 58.7 (13.6) years)
• Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial  + (Mean age (SD) per arm: Aloe arm: 46.25(18.17) years Placebo arm: 47.78(18.28) years)
• Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial  + (Mean age (SD) per arm: Aloe arm: 55.38 (17.99) years Placebo arm: 59.31 (15.03) years)
• Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor  + (Mean age (SD) per arm: Enzyme arm: 24.35 (5.57) years Control arm: 23.76 (5.48) years)
• Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme  + (Mean age (SD) per arm: Enzyme-arm: 62.0 (11.3) years Control-arm: 64.5 (9.3) years)
• Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study  + (Mean age (min-max) per year: Aloe arm: 60 (38-91) years Placebo arm: 54 (31-84) years)
• Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms  + (Mean age (range) per arm: Aloe arm: 63 (48-80) years Placebo arm: 61 (46-79) years)
• Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)  + (Mean age = 61 years Mean (SD) age per arm: THC = 60 (12) years Cannabis extract = 61 (12) years Placebo = 62 (10) years)
• Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy  + (Mean age of the participants = 56 years (Range: 18-84) Aloe arm: <45 years = 18%; 45-59 years = 55%; >60 years = 27% Control arm: <45 years = 18%; 45-59 years = 32%; >60 years = 50%)
• Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial  + (Mean age per arm: intervention arm = 63.5 years placebo arm = 63.8 years)
• Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms  + (Mean age per arm: Aloe arm = 57 years Placebo arm = 55 years)
• Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial  + (Mean age per arm: Enzyme arm: 53.8 years Placebo arm: 57.3 years)
• Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer  + (Mean age per arm: Enzyme-arm: 60.9 years Placebo-arm: 58.0 years)
• Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial  + (Mean age: 58.2 years, min = 32, max = 78, Median = 58.5 years)
• Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial  + (Mean value (range): Intervention arm: 60 years (32-74 years), Placebo arm: 58 years (39-83 years))
• Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial  + (Mean value = 56.5 years; range: 29-76 years)
• Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients  + (Mean(SD) Intervention arm: 63.83(9.2) years Control arm: 63.03(10.5) years)
• Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients  + (Mean(SD) = 63.5(9.31) years)
• Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer  + (Mean(SD): 47.3(9.26) years)
• Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting  + (Mean(SD): 47.3(9.26) years)
• Montazeri et al. (2013): Effect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients  + (Mean(SD): 50.3 (13.1) years)
• Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens  + (Mean(SD): 50.53 (12.21) years)
• Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia  + (Mean(SD): 63(12) years)
• Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients  + (Mean(SD): Intervention: 52.70±10.55, Placebo: 52.69±15.56 years)
• Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study  + (Mean: 45 years Range: 20-70 years)

• Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer  + (Mean: 48.5 years)

• Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study  + (Mean: 49 years Range: 32-68 years)
• Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders  + (Mean: 53)
• Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients  + (Mean: 53 years)
• Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer  + (Mean: 57.2)
• Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer  + (Mean: 72.8 years)
• Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial  + (Mean; median; range in years: Intervention arm 33.3; 32; 18-55 and placebo arm 34; 32; 18-55)
• Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial  + (Median (IQR): 68 (61-75))
• Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial  + (Median (range) of all participants = 57.6 (24-84) years Mean (SD) age per arm: Aloe arm = 55.7 (15.4) years Placebo arm = 58.7 (15.9) years)
• Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial  + (Median (range) per arm: - intervention: 60 (31-74) - control: 61 (31-75))
• Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131  + (Median (range): 42 (18-73) years)
• Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer  + (Median (range): 61 (19-91), per arm: - vit. A: Median 61 (23-83) - NAC: 61 (28–86) - vit. A + NAC: 61 (23–83) - control: 60 (19-91))
• Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia  + (Median (range): 64 (44-82))
• Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities  + (Median Age (SD) per arm: Polyphenon E arm: 63.4 (5.9) years, placebo arm: 61.3 (5.7) years)
• Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study  + (Median Age (min-max) per arm: Green tea arm: 55 (33-81) years, Metronidazole arm: 46 (35-81) years)
• Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue  + (Median age (minimum-maximum) per arm: Aloe vera arm = 56 (28-89) years Placebo arm = 60 (34-84) years)
• Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer  + (Median age (range) Poly E arm (all): 52 (36-64) years Placebo arm: 53.5 (40-59) years)
• Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer  + (Median age (range) per arm: Aloe arm = 55 (30-74) Placebo arm = 59 (26-76))
• Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer  + (Median age (range) per arm: Aloe arm: 64 (61-77) years Control arm: 65 (58-79) years)
• Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial  + (Median age (range): 55 (29-80) years)
• Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study  + (Median age: 54, Range: 18-71)
• Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial  + (Median age: 66 years)
• Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer  + (Median age: 69 (24-79))
• Meyskens et al. (1995): Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial  + (Median per group: - intervention group: 51 - control group: 46)
• Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study  + (Median: 47, Range: 24-70 years)
• Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial  + (Median: 51)