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List of results

• Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer  + (Early breast cancer)
• Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study  + (Early stage I or II)
• Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers  + (Enzyme-arm: T-Stage 0=2 T-Stage 1=1 T-S … Enzyme-arm: T-Stage 0=2 T-Stage 1=1 T-Stage 2=26 T-Stage 3=13 T-Stage 4=11</br></br>Control-arm: T-Stage 0=4 T-Stage 1=3 T-Stage 2=18 T-Stage 3=8 T-Stage 4=14</br></br></br>Enzyme-arm: N-Stage 0=17 N-Stage 1=23 N-Stage 2=10 N-Stage 3=2 N-Stage x=1</br></br>Control-arm: N-Stage 0=18 N-Stage 1=18 N-Stage 2=11 N-Stage 3=0 N-Stage x=0 </br></br></br>Site of disease per arm:</br></br>Alveolo-buccal: Enyzme-arm=21; control-arm=23</br></br>Tongue: Enzyme-arm=19; control-arm=19</br></br>Others: Enzyme-arm=13; control-arm=12=19 Others: Enzyme-arm=13; control-arm=12)
• Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology  + (FIGO Stadium I-IV)
• Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial  + (FIGO Stadium I-IV)
• Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131  + (Free of cancer metastases)
• Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients  + (Head and Neck cancer - Advanced Stage Gynecologic cancer - FIGO Stadium I-IV)
• Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck  + (Head and Neck region; stage III or IV)
• Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor  + (Hematological tumor classification in enyz … Hematological tumor classification in enyzme arm; control arm:</br></br>Acute lymphoblastic leukemia: 13 (36.11%); 12 (33.33%) </br></br>Acute non-lymphocytic leukemia: 11 (30.56%); 9 (25.00%) </br></br>Aplastic anemia: 5 (13.89%); 6 (16.67%) </br></br>Non-Hodgkin's lymphoma: 4 (11.11%); 5 (13.89%) </br></br>Langerhans cell histocytosis: 3 (8.33%); 4 (11.11%)s cell histocytosis: 3 (8.33%); 4 (11.11%))
• Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms  + (Histologically confirmed Stage II-IVM0 car … Histologically confirmed Stage II-IVM0 carcinoma of the head and neck</br></br>Primary tumor site (n): </br></br>Oral cavity: Aloe = 1 (4%); Placebo = 8 (27%)</br></br>Oropharynx: Aloe = 9 (32%); Placebo = 2 (7%)</br></br>Larynx: Aloe = 6 (21%); Placebo =7 (23%)</br></br>Hypopharynx: Aloe = 2 (7%); Placebo = 1 (3%)</br></br>Nasopharynx: Aloe = 4 (14%); Placebo = 6 (20%)</br></br>Unknown primary: Aloe = 4 (14%); Placebo = 1 (3%)</br></br>Other: Aloe = 2 (7%); Placebo = 5 (17%)) Other: Aloe = 2 (7%); Placebo = 5 (17%))
• Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial  + (Hormone receptor positive invasive nonmetastatic breast cancer (Stage I-IIIB))
• Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study  + (Hospitalised patients with malodorous fungating malignant wounds.)
• Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597  + (IA (pT1N0) or IB (pT2N0))

• Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial  + (IA-IIIA)

• Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy  + (II – IV)
• Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial  + (III and IV)
• Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial  + (Invasive cancer)
• Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy  + (Involved patients with a diagnosis of breast cancer at any stage)
• Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study  + (Locally advanced or metastatic breast cancer Cancer stage, n (%) per arm: Neo-adjuvant: intervention: 25 (83.3), comparison: 19 (63.3) Metastasizing: intervention: 5 (16.7), comparison: 11 (36.7))
• Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9  + (Lymph node involvement 0–3 intervention arm: 93 (87 %), placebo arm: 89 (86 %) ≥4 intervention arm: 14 (13 %), placebo arm: 14 (14 %))
• Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial  + (Mainly new cases of advanced breast cancer diagnosed by the oncologist)
• Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment  + (Mamma carcinoma stage III-IV)
• Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients  + (Mammacarcinoma stage I-III)
• Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial  + (Mean (SD) duration = 3.6 (4.8) years)
• Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain  + (Mean (SD) duration of cancer: 3.5 (4.4) years)
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Mean (SD) time since cancer diagnosis per arm: Sativex = 4.1 (4.2) years Placebo = 3.5 (5.0) years)
• Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators  + (Metastatic adenocarcinoma of the prostate with evidence of progression)
• Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer  + (Metastatic colorectal cancer)
• Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer  + (Metastatic prostate cancer)
• Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial  + (N (%) per arm: - intervention: 77 (74) stage I, 27 (26) stage II - control: 72 (65.5) stage I, 38 (34.5) stage II)
• Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer  + (N per arm: - intervention: 9x stage I-II, 16x stage III-IV - placebo: 6x stage I-II, 14x stage III-IV)
• Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer  + (NA)
• Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients  + (NA)
• Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis  + (NA)
• Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation  + (NA)
• Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy  + (NA)
• Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial  + (NI)
• Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial  + (NI)
• Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial  + (NI)