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- Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (Not operable Pancreas carcinoma, stage IV)
- Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer + (Number per group: - intervention: 17x I, 19x II, 14x III and IV - placebo: 18x I, 20x II, 18x III and IV)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Patients in different stages of complete remission: CR1, CR2, CR3)
- Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (Patients with carcinomas in the floor of the mouth)
- Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Patients with stage I/II/III in % - overall: 13/41/46 - intervention arm: 22/30/48 - placebo arm: 5/51/44 Significant difference between arms (p=0.031): intervention arm with earlier stages at diagnosis of cancer when compared with the placebo arm)
- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Patients with untreatable locally advanced … Patients with untreatable locally advanced or metastatic solid tumors and a life expectancy <6 months</br></br></br>Tumor histotype: </br></br>Non-small cell lung cancer: Control arm = 11; Aloe arm = 12</br></br>Gastrointestinal tract tumors: Control arm = 9; Aloe arm = 7</br></br>Breast cancer: Control arm = 4; Aloe arm = 3</br></br>Brain glioblastoma: Control arm = 2; Aloe arm = 2n glioblastoma: Control arm = 2; Aloe arm = 2)
- Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (People with metastases outside the abdomin … People with metastases outside the abdominal area were excluded. </br></br>Karnovsky Index >50%</br></br></br>Abdominal cancer types in enzyme arm; in control arm:</br></br>Ovarian carcinoma: 2; 2</br></br>Uterine carcinoma: 11; 15</br></br>Prostate carcinoma: 14; 2</br></br>Intestinal carcinoma: 3; 7</br></br>Hypernephroma (with pelvic metastases): 1; 1</br></br>Carcinoma of the vas deferens: 1; - </br></br>Head and neck carcinoma: 1; -</br></br>Bladder carcinoma: 1; -</br></br>Non-Hodgkin's lymphoma: -; 1</br></br>Chronic lymphocytic leukemia: -; 1</br></br>Vaginal carcinoma: 1; 2</br></br>Rectal carcinoma: - ; 1</br></br>Double carcinoma: 1; -ctal carcinoma: - ; 1 Double carcinoma: 1; -)
- Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Per arm, n stage I/n stage II/n stage III: - vit. A: 395/167/85 - NAC: 371/176/95 - vit. A + NAC: 376/182/85 - control: 382/184/77)
- Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer + (Per group n (%) - intervention: in situ 6 (4%), I 83 (62%), II 45 (34%) - placebo: in situ 7 (5%), I 82 (64%), II 40 (31%))
- Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (Radiotherapy field >33% of the buccal mucosa and ECOG 0‐2)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Second- and third‐stage colorectal cancer)
- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Stage I - IV)
- Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Stage I and II)
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Stage I or II)
- Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients + (Stage I or stage II cancer, n (%) of stage II disease per arm: - intervention: 101 (37) - placebo: 107 (40))
- Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients + (Stage I or stage II cancer, n (%) of stage II disease per arm: - intervention: 101 (37) - placebo: 107 (40))
- Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients + (Stage I or stage II cancer, n (%) of stage II disease per arm: - intervention: 101 (37) - placebo: 107 (40))
- Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (Stage I-III)
- Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (Stage I-III)
- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (Stage I-III)
- Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Stage I-III (non-metastasised) hormone receptor–negative breast cancer Breast cancer stage at diagnosis: n(%) I: Poly E arm: 14(47) Placebo arm: 2(20) II Poly E arm: 9(30) Placebo arm: 6(60) III Poly E arm: 7(23) Placebo arm: 2(20))
- Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (Stage I-IV)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Stage I: n=5 Stage II: n=35 Stage III: n=15 Stage IV: n=5)
- Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (Stage II)
- Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer + (Stage II or III breast cancer, no significant differences between arms in cancer stage (p > 0.05))
- Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer + (Stage II, III, or IV)
- Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Stage II-IV and recurrent cancer)
- Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Stage III and IV)
- Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (Stage IV colorectal cancer and hepatic metastases)
- Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (Stage I–III hormone receptor positive breast cancer)
- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (Stage of disease per arm (n): Enzyme arm: Ib = 2, IIb = 16, IIIb = 42 Control arm: Ib = 0, IIb = 19, IIIb = 41 Performance status (WHO) per arm (n): Enzyme arm: 1 = 54, 2 = 6 Control arm: 1 = 51, 2 =9)
- Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Stages I to III)
- Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Stages I-IV and primary and recurrent tumors)
- Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Stages I-IV and primary and recurrent tumors)
- Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Stages T1-3, N0-1, M0)
- Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (State I-II)
- Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (Survivors)
- Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (T-Stage per arm: Aloe vera arm: 1 = 67; 2 = 38; 3 = 2; unknown = 0 Placebo arm: 1 = 67; 2 = 29; 3 = 1; unknown = 4)
- Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (T1-2, M0)
- Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (T1-2, M0)
- Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (T1-TX, N0-NX, M0-MX)
- Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Ta/T1, N0/NX, M0)
- Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (The range of disease stages, based on pathologic evaluation, did not differ among patients enrolled in the two arms)
- Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (Transurethral resected urinary bladder carcinoma (non-invasive urinary bladder carcinoma, Ta, T1, Tis))
- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Tumor site: Oropharynx = 41; Nasopharynx = 26; Larynx = 13; Hypopharynx = 11; Oral cavity = 9; Unknown = 4 T-classification: T0=4; T1=17; T2=35; T3=27; T4=21)
- Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Tumor site: Head/neck: Aloe arm = 39%; Control arm = 43% Chest: Aloe arm = 58%; Control arm = 52% Abdomen/pelvis: Aloe arm = 0%; Control arm = 3% Extremities: Aloe arm = 3%; Control arm = 2%)
- Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Tumor stage per arm: Aloe arm: 1 = 0; 2 = 0; 3 = 9 (69.2%); 4 = 4 (30.8%) Placebo arm: 1 = 0; 2 = 0; 3 = 7 (53.8%); 4 = 6 (46.2%))
- Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Tumor staging Aloe arm: T1 = 3 (10%); T2 = 8 (28%); T3 = 6 (21%); T4 = 12 (41%) Placebo arm: T1 = 5 (16%); T2 = 8 (26%); T3 = 6 (19%); T4 = 11 (36%); Unknown = 1 (3%))
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Tx-T4 (50% T2), N0-N3 (55.6% N0), Mx-M1 (83.3% M0))
- Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (Type of disease: Acute Myeloid Leukemia (AML): Control arm = 17 (26.6%); Aloe arm =10 (15.6%) Acute Lymphocytic Leukemia (ALL): Cobtrol arm = 15 (23.4%); Aloe arm = 22 (34.4%))
- Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy + (n=28 stage I-II, n=38 stage III-IV, n=6 unknown)