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List of results

Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (2x 2 Placebo capsules daily, from 3 days before chemotherapy for 12 weeks or until the end of chemotherapy)
Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer + (2x 200 mcg tablets of selenium (Webber Naturals, Coquitlam, BC, Canada) daily from the first day until the end of radiation (including days without radiation exposure))
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (2x a day, preferably taken before lunch and dinner/at bedtime)
Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9 + (2x daily)
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (2x daily 7 days before chemotherapy, during chemotherapy 1x daily, and daily for 3 weeks after chemotherapy)
Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (2x daily Wobe Mugos microclysms, 5g each, for 1 to 4 weeks (average 2 weeks) and further outpatient treatment with dragees + all patients: Poly-chemotherapy (Fluoro-Uracil, Vinblastin, Metothrexat, Cyclophosphamid))
Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer + (2x placebo tablets daily from the first day until the end of radiation (including days without radiation exposure))
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (2x/day, every 12 hours (50 mg, Charge E16117007))
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (2x/day, every 12 hours (50 mg, Charge E16117007))
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (2x1 placebo capsules 250mg 2x2 ginger capsules ((liquid extract from ginger root in virgin olive oil + excipients and placebo capsules, 1.0g ginger daily))
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (2x2 6-gingerol capsules daily (5mg each, standardized), from 3 days before chemotherapy for 12 weeks or until the end of chemotherapy)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (2x2 placebo capsules 250mg 2x1 ginger capsules (liquid extract from ginger root in virgin olive oil + excipients and placebo capsules, 0.5g ginger daily))
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (2x250 mg every 12 hours from the first day of chemotherapy)
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (2x250mg (5% gingerol) every 12 hours from the first day of chemotherapy)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (2x3 placebo capsules)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (3 times daily, 4 capsules each time Duration: 7 weeks (entire radiationtherapy))
Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy + (300 mg daily, orally Start: before chemotherapy (Median: 4 days prior (Range: 1-8)) Duration: until 3 months post-chemotherapy)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (30min., 1x week, 4 weeks in total)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (30min., 1x week, 4 weeks in total)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (30min., 1x week, 4 weeks in total)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (37.5 mg by mouth, 2x/day Starting after 1 week of chemotherapy, for 3 weeks Depending on the improvement or stabilization of the BFI scores: randomized assignment to a placebo for another 3 weeks)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (37.5 mg by mouth, 2x/day Starting after 1 week of chemotherapy, for 3 weeks Depending on the improvement or stabilization of the BFI scores: randomized assignment to either the continuation of PC-18 at the same dose)
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine + (3g (6 capsules each (hydrochloride, cellulose, 500mg ALC)) daily for 24 weeks)
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (3g (6 capsules each (hydrochloride, cellulose, 500mg ALC)) daily for 24 weeks)
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (3x 1g daily + 549mg)

Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (3x 220mg zinc sulfate capsules, daily)

Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (3x daily (including immediately after trea … 3x daily (including immediately after treatment on treatment days) topical aqueous cream on the irradiated breast during and for 2 weeks after radiation therapy+ all patients: routine skin care recommendations: using only mild baby soap on the treatment site, airing skin twice daily, and wearing loose cotton clothing next to treated skin+ all patients: radiation therapyed skin + all patients: radiation therapy)
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (3x daily (including immediately after trea … 3x daily (including immediately after treatment on treatment days) topical 98% aloe vera gel on the irradiated breast during and for 2 weeks after radiation therapy+ all patients: routine skin care recommendations: using only mild baby soap on the treatment site, airing skin twice daily, and wearing loose cotton clothing next to treated skin+ all patients: radiation therapyed skin + all patients: radiation therapy)
Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (3x placebo capsules, daily (similar in shape, taste, and color))
Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (3x3 tablets WOBE-MUGOS E (10mg papain, 40m … 3x3 tablets WOBE-MUGOS E (10mg papain, 40mg trypsin, 40mg chymotrypsin) daily, starting 3 days before the first radiotherapy treatment over a period of 54(+/-9) days until 5 days after completion of radiation therapy+ all patients received 50 to 70 Gy telecobalt therapy using a standard daily radiation dose of 2 Gy in 25-35 fractions over a period of 6-7 weeks25-35 fractions over a period of 6-7 weeks)
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (3x4 capsules of of WOBE-MUGOS containing e … 3x4 capsules of of WOBE-MUGOS containing each 100 mg papain (270 FIPE), 40 mg trypsin (29 ukat) and 40 mg chymotrypsin (200 ukat) daily, starting 3 days before irradiation and finishing on the last day of radiotherapy+ all patients: radiation using a four-field box technique with individually shaped blocks; external beam radiotherapy was given using fractionation of 5 x 1.8 Gy weekly to a total dose of 50.4 Gy, specified at the isocentreose of 50.4 Gy, specified at the isocentre)
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (3x4 capsules without any enzyme contentsda … 3x4 capsules without any enzyme contentsdaily, starting 3 days before irradiation and finishing on the last day of radiotherapy+ all patients: radiation using a four-field box technique with individually shaped blocks; external beam radiotherapy was given using fractionation of 5 x 1.8 Gy weekly to a total dose of 50.4 Gy, specified at the isocentreose of 50.4 Gy, specified at the isocentre)
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (3x4 tablets of WOBE-MUGOS E daily, startin … 3x4 tablets of WOBE-MUGOS E daily, starting 3 days before the first radiotherapy dose until 5 days after the last dose of radiotherapy.The verum (Wobe-Mugos E) contained papain 100 mg, trypsin 40 mg, and chymotrypsin 40 mg.+ all participants: Radiotherapy protocols comprised conventional fractionation with 1.8–2.0 Gy/fraction, 5× per week to total doses of 60–66 Gy per 6–7 weeks, or hyperfractionation with 2 × 1.2 Gy per day, 5× per week to a total dose of 72 Gy per 6–7 weeks.Hyperfractionation was applied in 8 (22%) patients in the Wobe-Mugos E armn 8 (22%) patients in the Wobe-Mugos E arm)
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (3x4 tablets of placebo daily, starting 3 d … 3x4 tablets of placebo daily, starting 3 days before the first radiotherapy dose until 5 days after the last dose of radiotherapyThe placebo tablets were looking identical and contained ludipress, corn starch, magnesium stearate, cellulose, mikri, silicic acid, Capol 600, saccharose, talcum, vanilline, calcium carbonate, titanium dioxide, soluble polyvinylpyrrolidone, white clay, Pek 6000, isopropanol, Eudragit L 12,5 P.+ all participants: Radiotherapy protocols comprised conventional fractionation with 1.8–2.0 Gy/fraction, 5× per week to total doses of 60–66 Gy per 6–7 weeks, or hyperfractionation with 2 × 1.2 Gy per day, 5× per week to a total dose of 72 Gy per 6–7 weeks.Hyperfractionation was applied in 11 (33%) patients in the placebo arm.d in 11 (33%) patients in the placebo arm.)
Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (3x5 tablets of WOBE-MUGOS (100mg papainases, 40mg trypsin, 40mg chymotrypsin, 40mg hydrolysate from calf thymus) daily 30 minutes before a meal + all patients: radiation therapy with a cumulative total radiation dose of approximately 50 Gy)
Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (3x5 tablets of Wobenzym daily for 6.5 weeks + all patients: 2x daily CDT (combined decongestive therapy) for the first 20 days, consisting of manual lymphatic drainage (neck, arm, thorax), bandaging of the arm, specially tailored exercises and skin care)
Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (4 Zinco‐C 25‐mg tablets daily)
Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (4 placebo oral capsules each morning with food for 3 to 6 weeks until the day before surgery)
Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (4 polyphenon E oral capsules (200 mg EGCG per capsule = 800mg ECGC) each morning with food for 3 to 6 weeks until the day before surgery)
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (4 sessions for 1 h each, spread over an average of 10 weeks)
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (4 sessions, no information regarding duration of therapy)
Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (4 μg of 1,25(OH)2 D for each of 3 sequential days, followed by 4 days of no treatment)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (400 IU/d of vitamin D3 during all cycles (one 400 IU capsule plus 1 placebo capsule during cycle 1))
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (400 IU/d of vitamin D3 during all cycles (one 400 IU capsule plus 1 placebo capsule during cycle 1))
Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial + (400 mg daily Duration: until 6. chemotherapy cycle)
Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy + (400 mg daily, orally Start: before chemotherapy (Median: 3 days prior (Range: 1-8)) Duration: until 3 months post-chemotherapy)
Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy + (400 mg daily, orally Start: before chemotherapy (Median: 3 days prior (Range: 1-8)) Duration: until 3 months post-chemotherapy)
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (4200 mg/day (3x4 capsules/day) Starting with the first day of radiotherapy, Ending with the last day of radiotherapy)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (45 mg zinc sulfate orally 3 times daily after meals, Duration: start within 7 days of the initiation of radiotherapy and continue for another 4 weeks after radiotherapy completion)
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (4g daily Duration: 12 weeks)
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (4x 250mg ginger capsule (production not standardized) + antiemetics Start: 2 capsules 30 minutes before the start of chemo, 2 capsules 6 hours after the end cross-over after cycle)