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• Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial  + (3x4 capsules without any enzyme contentsda … 3x4 capsules without any enzyme contentsdaily, starting 3 days before irradiation and finishing on the last day of radiotherapy</br></br>+ all patients: radiation using a four-field box technique with individually shaped blocks; external beam radiotherapy was given using fractionation of 5 x 1.8 Gy weekly to a total dose of 50.4 Gy, specified at the isocentreose of 50.4 Gy, specified at the isocentre)

• Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial  +